Автореферат (1155053), страница 7
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Большинство рассмотренных методов пока находиться на стадии разработки и некоторые методы постепенно находят практическое применение за рубежом в медицине и др. областях. Существует возможность использования клеточных носителей (КН) в качестве системы доставкиVCR и VBL.
В научных публикациях пока отсутствуют данные о применении КН для инкапсулирования VCR и VBL.Поэтому актуальны исследования, посвящённые возможности применения КН для уменьшения побочных эффектов,улучшения эффективности и разработки лекарственных форм доставки VCR и VBL в патологические очаги.Halahakoon Mudiyanselage Amila Jeewantha Halahakoon(The Democratic Socialist Republic of Sri Lanka)THE OBTAINED AND STANDARDIZATION OF ENCAPSULATED ERYTHROCYTES CARRIER WITH TERPENE-INDOLES ALKALOIDS ANTICANCER DRUGSOncological diseases remain one of the most dangerous. According to WHO, there are 10 million new cases everyyear were reported.
Antitumor chemotherapy is one of the most important and fastest growing departments of modern oncology. Currently, in anticancer chemotherapy uses different modes and various groups of anticancer drugs (antimetabolites,cytostatic, alkylating compounds, etc.). Anticancer drugs of plant origin vincristine and vinblastine (VCR and VLB), whichbelong to the terpene-indole alkaloids (TIAs) of C. roseus are subject to highly cytostatic activity. Their low selective effecton the tumor leads to the effects of drugs on many healthy organs and tissues in the patient's body.
In antitumor chemotherapypractice, VCR and VLB are used in mono- and combined schemes and regimens in the treatment of various cancer types.Despite their effectiveness, there are numbers of side effects that limit the use of these drugs. The goals of modern pharmaceutical science and production are aimed at improving the Pharmacokinetic Profile of TIAs drugs for: reducing side effects,targeted delivery of TIAs drugs through controlled drug delivery systems (CDDS), use nanotechnology in the formation ofnew types of dosage forms (liposomal forms, micelles, dendrimer, microparticles, nanoparticles), etc. The search and development of ways to reduce the adverse effects of TIAs drugs in the body and improve the tolerability and effectiveness of chemotherapy is Relevant project.
Over the past few decades, the technology controlling the delivery of drugs has advanced significantly, which leads to the development of various ways to improve the quality of drug delivery. It is very important to developmethods for their standardization and quality control. The literature currently reflects the basic aspects of the theory and practiceof the directed transport of drugs, the generation of dosage forms, through which the delivery of drugs to the target organ iscarried out.
One of the most effective and accessible for use (safety, technical simplicity, rapid achievement of clinical resultsat a relatively low cost of the procedures) are methods of directed transport of drugs, involving the use of auto-logical bloodcells as carriers of drugs. Most of the considered methods are still under development and some methods are gradually findingpractical application abroad in medicine and other fields. It is possible to use cellular carriers (CC) as a delivery system forVCR and VBL. Scientific publications do not yet have data on the use of CC for encapsulation of VCR and VBL. Therefore,relevant research on the possibility of the use of CC to reduce side effects, improve the efficiency and development of dosageforms of delivery of VCR and VBL in pathological foci.26.
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