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Дляверификации латентного миокардита дополнительно применялись визуализирующиеметодики (магнитно-резонансная томография, перфузионная сцинтиграфиямиокарда). На III этапе исследования при обследовании 56 детей,госпитализированных в 2001–2015 годы с острой ревматической лихорадкой, былаохарактеризована современная структура заболевания и патоморфоз его клиническихпроявлений как наиболее тяжелой формы сопряженной тонзиллогенной патологии,основными особенностями которой были: высокая частота хореи; частое развитиеатипичного суставного синдрома; высокий процент формирования хроническойревматической болезни сердца и ревматических пороков сердца.Yulia Yurievna Novikova (The Russian Federation)“Markers of streptococcal infection and myocardial injury and markers ofautoimmunity in children with chronic tonsillitis”The dissertation is devoted to the identification of risk groups for cardiovasculardisease in children with chronic tonsillitis by using a comprehensive assessment of markersof streptococcal infection and myocardial injury and markers of autoimmunity.
The studyincluded 182 children (97 boys and 85 girls) aged 4 to 17 years (Me 11 [8;14]) with chronictonsillitis with/without various cardiovascular complaints and electrocardiographic changes.The study consisted of three stages. We developed a three-step algorithm for the diagnosisof myocardial injury in chronic tonsillitis using common laboratory tests, heart tests(electrocardiography and echocardiography), markers of streptococcal infection and markersof autoimmunity. Cardiac autoantibodies (by ELI-ANCOR-Test) were used to determine thepresence of myocardial injury. Medical imaging techniques (magnetic resonance imaging,myocardial perfusion scintigraphy) were used to identify chronic latent myocarditis.
At thethird stage the study included 56 children, who were hospitalized in 2001-2015 with acuterheumatic fever. Acute rheumatic fever is a nonsuppurative cardiovascular complication ofthe group A β-hemolytic streptococci tonsillopharyngitis. The results of our studydemonstrate that the clinical features of acute rheumatic fever are characterized by the highfrequency of Sydenham's chorea and atypical arthritis, the high frequency of rheumaticheart disease..
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