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. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .60Èìèòàöèÿ ðàçâèòèÿ ÑÊ â òå÷åíèå 200 ñóòîê. Ñëåâà ïðåäñòàâëåíû ðåçóëüòàòûâû÷èñëèòåëüíîãî ýêñïåðèìåíòà íà ìîäåëè â ñëó÷àå Th2 èììóííîãî îòâåòà,ñïðàâà â ñëó÷àå Th17 èììóííîãî îòâåòà.5.4.. .
. . . . . . . . . . . . . . . .Îòíîøåíèå ìåæäó êîíöåíòðàöèÿìè Â-ëèìôîöèòîâ ( , ) è àíòèòåë ( , )â ñëó÷àå Th17 è Th2 èììóííîãî îòâåòà â òå÷åíèè 200 äíåé çàáîëåâàíèÿ.5.5..65Óðîâåíü C1q (), àíòèãåíà ( ) è êîìïëåêñîâ àíòèãåí-àíòèòåëî ( ), àíòèãåíàíòèòåëî-C1q ( ) â êðîâè, ìîëü/ë.5.6.64. . . . .
. . . . . . . . . . . . . . . . . .66Ýëèìèíàöèÿ èììóííûõ êîìïëåêñîâ ñ ïîìîùüþ ýðèòðîöèòàðíîãî ðåöåïòîðàCR1 () óðîâåíü ðåöåïòîðà áûñòðî ïàäàåò, â ðåçóëüòàòå ÷åãî îí ñòàíîâèòñÿàáñîëþòíî íåýôôåêòèâåí.6.1.. . . . . . . . . . . . . . . . . . . . . . . . . . . .67Îáùàÿ ñõåìà èììóííîãî îòâåòà: I ôàãîöèòîç (çàõâàò) àíòèãåíà äåíäðèòíûìèêëåòêàìè è Â-ëèìôîöèòàìè è ñëåäóþùèé çà ýòèì ïåðåõîä òàêèõ êëåòîê âñîñòîÿíèå ÀÏÊ; II ïðåçåíòàöèÿ àíòèãåíà â ëèìôîóçëå íàèâíûì (ò. å.íåâñòðå÷àâøèìñÿ ðàíåå ñ àíòèãåíîì) Òh ëèìôîöèòàì è àêòèâàöèÿ ïîñëåäíèõ;IIIàêòèâàöèÿÒñèÂ-ëèìôîöèòîâ÷åðåçâçàèìîäåéñòâèåñÀÏÊèàêòèâèðîâàííûìè Òh ëèìôîöèòàìè; IV ïðîëèôåðàöèÿ è äèôôåðåíöèðîâêàTh,TcèÂ-ëèìôîöèòîâ;VâûõîääèôôåðåíöèðîâàâøèõñÿTcèÂ-ëèìôîöèòîâ (ïëàçìîöèòîâ) èç ëèìôîóçëà è ðåàëèçàöèÿ èììóííîãî îòâåòà ÷åðåçóíè÷òîæåíèå çàðàæåííûõ êëåòîê è ñèíòåç àíòèòåë, ïðè÷åì òèï ñèíòåçèðóåìûõïëàçìîöèòàìè àíòèòåë çàâèñèò îò íàëè÷èÿ îïðåäåëåííûõ ñòèìóëîâ ñî ñòîðîíûTh ëèìôîöèòîâ. ñêîáêàõ óêàçàíû íàçâàíèÿ ñîîòâåòñòâóþùèõ ïåðåìåííûõìàòåìàòè÷åñêîé ìîäåëè..
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . .8069Ñïèñîê òàáëèö3.1.Ñðåäíåå ðàñïðåäåëåíèå êëåòîê ïî ôåíîòèïàì ñîãëàñíî ýêñïåðèìåíòàëüíûìäàííûì (äîëÿ îò îáùåãî ÷èñëà êëåòîê). . . . . . . . . . . . . . . . . . . . . . .395.1.Êîýôôèöèåíòû (÷àñòü 1). . . . . . . .
. . . . . . . . . . . . . . . . . . . . . . .565.2.Êîýôôèöèåíòû (÷àñòü 2). . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .575.3.Êîýôôèöèåíòû (÷àñòü 3). . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .585.4.Òàáëèöà ýêñïðåññèè ÐÍÊ Th öèòîêèíîâ â çàâèñèìîñòè îò ÷èñëà ïðîéäåííûõäåëåíèé5.5.,êàê îòíîøåíèå ê ýêñïðåññèè HPRT ñîãëàñíî [120]. . . . . . .
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