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All of them received therapy with gestagens or GnRHagonists and additionally EGCG at a dose of 180 mg/day for 6 months. A pronounced tendency todecrease the incidence of methylation of oncosuppressor genes after combined therapy with EGCGwas revealed.A placebo-controlled study of an indole-3-carbinol drug (44 patients with cyclic mastalgiaand benign mammary dysplasia) was performed at a dose of 200 mg twice a day.
The ratio of 2-OHE1/ 16α-OHE1 in the urine in the active drug group increased in 82% of patients, and in the controlgroup only in 43%, which correlated with clinical improvement.A hypothesis has been formulated that the pathophysiology of early carcinogenesis in thereproductive system consists of a complex of molecular and genetic changes that include hormonalhyperstimulation, epigenetic blockade of oncosuppressor genes and activation of proto-oncogenes,and a shift in the balance of growth factors and cytokines to stimulate proliferation with a decreaseactivity of factors that inhibit proliferation.50ООО «Хорошая типография»Подписано в печать 01.06.17, тираж 150 экз.г.
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