Сведения о результатах публичной защиты (1145652), страница 3
Текст из файла (страница 3)
OrsbIBrloJroxlrrelturrfi , 3 aMer{ aHl4fi tte coAepx(I{T.Bor3brBax Ha aeropeQepar orMer{aercfl aKTyanbHocrb 14 3HarlrlMocrbvsyrqeHutr porur PHK-csq3brBaroqr4x6emon B pa3BllTtrvv Synr<qzoHrrpoBaHl4uMo3ra.Bo Bcex or3blBax npuayrcrByero roM, rrro colrcKareJlb3aKJIIoqeHI,le3acnyxr4Baer npr,rcB eHr4fl yueuofi crerleHu KaHAI4Aara 6uonoruqecKHx HayK.BgSopobooorzqraanbHblx oIIIoHeHToBcuonrrB aercfl BbrcoKofireHerr4Kr4 QopnlupoBaHnfl.r<nanran14 re4yrqefi opraHI43aIII4I4Bbr6p aHHbIX creIII4aJII4croB B o6nacrl4sur a\uefrQyurquoHllpoBaHl4-a Mo3ra, K Koropr,IM orHocHTc.flALrccepraIII4 oHHa.lt p a6 ora,r{To Ha ocHoBaHI4I4 BbITTOJIHOHHbIXflraccepraquonuslfi coBer orMerlaer,coqcKarerreM rrccJre4oeauufi paspa6oraHa HayqHafl Lr!.es. corrlacHo rcoropofi ynro4oeofi MyrxKrr Drosophila melanogaster Selor SBR (Dm NXFI), SyttKIII4flKoroporo 3aKlroqaerc-rr B oSecne.reHl4l4 3Kctlopra Sonruruscrea N'IPHK rB fl'I.parIrlTorIJIa3My,BcI4ATeMe BblIIorH-seTuePnnoficneqZaJII43HpoBaHHbIe Syuxqrara, ueoSxoAI'IMbIeBAOTIOJIHT{TeJIbHbIe4.rIfl QopvzpoBalukIfl' AMoAeJIb, pacKpblBaroqatSyHxqHoHr{poBaHrz-f, Mo3ra 4posoQranrr.
IIpe4Jro}KeHarIToHoByro cilerl4aJrrr3r4poBaHHyro SyHTcIII{Io 6eJlra SBR B Mo3re, 14 AoKa3aHorAeOeKTbr SopurapoBaHnfl.3prrreJrbHbrx AoJIef Mo3rasbr'' B rerepo3r.rrore,B6elra SBR, o6pa:onaHnrre ruSoPH;I-rpauynBcyuleorBoBaHhecaMIIoB, HecylIIZXaJIJIeJIbflBr.f,rorcq cJreAcrBI{eM HapyueHvrfl. npoqecca HaBIdraUxLlaKcoHoB Soropeqe ropHbrx nefipouon.rpaHynbryorpocrKax ueupouon BLIflBJIeHbIdFMRI (ruaprepr{To yKa3blBaer HacoBMecrHo c Selrorultt6o 5es sroro 6elra,cuequsuqecKr4x uPHK-rvrzuteuefi, c KoropbIMI4 6eloruefipoHax),SBRcoxpaH,f,eT cB.[3b B I{I4TOIIJIa3Me.TeoperuqecKaq 3HaqIrMocr[, rrccJreAoBanttfl o6ocnoeaHa reM'BnepBbrey rrJtoAoBofi uyurxu D, melanogaster H3yrreHorese sbr (Dm nxfl) Ha SopMr{poBaHHeBIrvrflHvre pflI:ara SyHxIIuoHI{poBaHI4erITouyraqrafi nMo3ra 4po:oSranrr;sbrt2,AoKa3aHo, rrro HapyrxeHze @yurquv 6etxa SBR, oSycnonneHHoe AeleqzefisBr;rercq AoMr4HaHTHbrMB3JrJrrrncor4AHoM TeJrer4 rrpr4BoAr4T(o4znK Hapy[IeHI4Io $oprnlupoBaHvrfl' KoHHeKToMar43 oJIeMeHToB IleHTpanbHoro KoMnJIeKca Mo3fa,qerqroqr4ficq rrraBHbrM KoHTponnepoM JloKoMoropuofi axrunuocru) vuefiponulqx 3pr4TenbHbrx Aonefir4-JraMr4HeI{ MeAynne (yuacrnylor B npoBeAeHI4I4r{To ynepBr4anofi lepepa6orre BXoA-trrrII4x 3pI4TenbHbIX aI4rHaJIoB).
Ilona:aHorcaMrIoB, Hecyqnx aJrJreJrbsbr'tB rerepo3l4rore Ir I4MeIouIzx 4eQer<TbI crpyKTypblB Tecre Ha orpnuarelrgrtfr feoraKclac cHI4xeHa yxe BBo3pacre 3-5 cyror u npoAonxraer cHl{xarbcq ro Mepe B3pocnenu-fl oco6efi. B roxe BpeM-rr, y reTepo3l4forHbrx caMoK IIpof,BneHI'Ie aJIJIeJI s sbrt2 fBJIfeTc.a MeHeetyo3fa, aKTrrBHocrbBbrpax{eHlttblM: He npIIBoAI4To6yclauvBaerK [oqBIeHI4IocHZXeHr4e aKTr4BHoc'rr4CTpyKTypHbIX4e$erroe MO3ra' HoB Tecre Ha orpllllarerlbHblfr feoraKcl'tc,npu.renr n Sonee no3AHeM Bo3pacre, no cpaBHeHI4Io c raKoBbIMy caMuoe'odpasou, rroJryqeHbr HoBbre AaHr{bre, yKa3brBaroql4e HaKoMrreHcarlurc afl;ter-f, sbr]2xpoMocovuofi- y caMIIon (n aocraBe Sparnaeura X-xpoMocoMbl, repeHeceHHoro n Y-xpovrocovy)flpunaeHureJrbHoHepaBHoIIeHHyroe rerepo3rlrore B 3aBVeLrMocrI4 orJroKaJrrr3arJr4v annets sbr*'.
e Y-xponrocoMeTarczNaran X-xpoMocoMeK npoOleiuaruKe Arrccepralluu- y caMoK.eQQenrunuorrpHMeHeH r4HTerpaJnuufi rroAXoA, coueralorqzfi MeroAbI Kraccl4r{ecKol4feHeTI4Kr4, AOBpeMeHHbre rII4TOnOfIIr{ecKI4e Vr gTOrIOfI4rIeCKI4e IOAXOAbI.trIsroxeurrAoKa3brBaroq[e, rrro y caMIIoB nlo4onofi MylrrKrr DrosophilaSarcru,melanogaster, tteeyulraxaJrJreJrbsbrt2 B rerepo3l4rore, uaSruoAaeMble4eQer<TbrcrpyKTypbr KoHHeKToMa JraMrrHbr r4 MeAyJIJIbI Mo3ra o6ycnonneHbl Hapy[IeHlIeMnpoqeccoB pocra aKcoHoB QoropeqenropHblx uefrpouon 14 Haxox(AeHl4t vMvrcBor4x uzurenefi, r{To conpoBox Aaercfl. rto.f,BreHlleM or{aron uefrpo4ereHepaqr4ttcoorBercrByrotqux oSnacr.sx Mo3ra. florcarano, rITonpoqeccbl rrpor4cxoA-f,T, Harrr4laflc:^rurlaroJlorr{rlecKl4erz.IuHo.{Hofi ara\vrv pa3Bvrrplfl' TaruuoSpa:ovr, pacKpbrr MexaHr{3M sOpVrrapoBaHprfl, 4eoer<ron crpyKrypbl JIaMI4HbIMeAynnbr Mo3faycaMuoBcHapyueHl{eM pa3nurlHblx aCIIeKTOB IIOBeIeHIlflHecyur.rx aJrJrenb sbrt2 B rerepo3lrfore.Il:yveuxapaKTep JIoKaJIrI3aqI'il4SBR.
B IlI4ToIIJIa3Me HepBHbIX KJIeToK. floKasaHor rIToMo3fa FIa nra.IuuoqHofi aral:vttBI4V6elrano Mepe $opttaupoBatnflpa3BlrzrTr4fl orIpeAeJIeHHbIe JrlllHurr KJIeroKo6orauleurr 6eryou SBR. llpracyrcrsze 6ema SBR B cocraBe HeKoropblx PHII-rpaHyn B orpocrKax Hefipouon yKa3brBaer Ha cyuecrBoBaHne onpe4eleHHblxvrPHK-vraureuefi,cKoropbrMr46e:ror SBR coxpaH-fler cB,s3b BUrITotIJIa3Me.CyruecrnoBaHr4e raKr4x vrPHK-rr,rraurenefi oSl,scHqer HapyueHrre SopnaupoBaHnflonpeoercHHbtx H9pBHLIX IISHTpOB Mo3rayCaMII9B, HeCyqI4X aJIneJIbSbr''BreTep03I4fore.3Ha.reHue lloryqeHHbrx coucr{areJreM pe3yJrbraroB HCCJTeAOBaHI{fl AJrfrrpaKTl{Krr olpeAeJr.rreTc-fi TeM, r{To B pa6oTe IIpeAcTaBJIeHbI HOBbIe AaHHbIe O5br (Dm nxfl) na pocrBJTI4flH4lg MyraI\vIi4 B sBonIoquoHHo-KoHcepBarI'IBHoM reHeB Mo3re' Blrcora'sKOHCSpBaTI4BHOST6 feHoB ceMefrcTBa nxf IIo3BoiIf,eTaKcoHoB HefipoHoB3BonIoIII4oHHa-f,vI ypoBeHbHefipoAereHepalll4l43Kcrpanolr.rpoBarb nolyqeHHble AaHHbIe Ha rreJloBeKa.
Pesylrrarbl Al4ccepTar\vrr4Moryr Srgr r4crroJrb3oBaHbr B crrerlKypcax Ha MeAI4III{HoKI4x ra 6uoloruqecKr'IxSar<ynrrerax Bblc[rzx o6pa3oBarenbHblx 3aBeAeHrrfioqenrca AocToBepHocTrr pe3yJrbTaToB'IICCIIeAOBaHVfl. BbIflBIdJIA, rITOpaSoTe npoBeAeH leTaJrbHbrfi a[aJrvr3 AaHHbIX IrO TeMeBI4CCJIeAOBaH]d[',B oreqecrBeHHbrx v 3apySexHblx I4CTOTIHUKaX; pe3ynbraTbl6utttu 1rony{eHbl c IIoMotUbIO CoBpeMeHHbIX reHeTZrIecKI4X,[peAcTaBJreHHbrxOKCII9pIIM9HT9BuIITOJIO|I4IIeCKI4X!13TOJIOTI4IIeCKIIX MeTOAOB, SKCnepIIMeHTbI BEInOJIHeHbI HAceprr4Or4rII,IpoBaHHoM oSopy4oeaHnl4,{auuue,npeAcTaBJIeHHbrevIIIoBTopeHbI AocTaTor{Hoe rluclto pa3'B pa6oTe, flBJIf,IOTCf,AOCTOB9pH6IMII14tITo TeopeTl4qecKl4e oSo6uteHl4q CoflacyloTcflBOClpor4:|BoAr4MbrMu.
vcranoBJreHo,c pe3ynb'raraMr4, nonyqeHHbrMr4 B pa6oTe z npeAcTaBJIeHHbIMI4 B JlrrrepaTypeTEMEI4CC JIE,4OBAHVfl.JluqnrrfiBceXI1oBKJTaA CorrcKarerqaKanepI4MeHTOB,cocrollT B HelOcpeAcrBeHHoM rIpoBeAeHHrIo6pa6orre,3KcnepI{MeHTaJrbHbIX AaHHbIX.I4HTepnpeTaI\LII4llO4rOroera pe3ynbTaTOBVIIpeAcTaBIIeHI4VI4CcJIeAOBaHzfl' 4.nflfly6nuKarlrafi n peqeH3r{pyeMbrx v3AaHVr-sX 6bUIa [poBeAeHa BMecTe c coaBropaMl',I:JI.A. MaMoH, E.B. fony6ronofi H B.P.
funanosofi. orAenbHble 3Kcrlepr{MeHrbl6ulu B1;III9JIH9HsI IIpII yqraaTur C.I4. Trauorueuro, qTo oTpaxeHo B TeKcTeAr{cc epra r\vrvv aBropeo e pT a.rITo AI4ccepTaIIu-sfuccepralllloHHblfi QoBeT npl,lrr1en K BbIBoAy o ToM,(B paMKax-,{KuMoeofi Annu OrerosHrr .rrBJrflercfl oprrrl4HaJlbHbrM, 3aKoHr{eHHbIMrrocraBJreHHbrx 3aAarr) HayrrHo-KBaJr4Or4KarIr4oHHbIM IlccJIeAoBaHI4eM, IIoJIHocrbroHa col4cKaHrlecre[eH1a KaHALrAara 6uolorzqecKlrx HayK (tt.9. noJloxeHl4fl (O nopqAKelpr4cylxA eHzrfl.
yqeHbrx creneuefi>>, yrBepllqeHHoro IIocranonJIeHI{eMorBeqaroulr4M Tpe6oBaHLrflM) rrpeAb-rrBnqeMblM Al4ccepraUl4flMflpanrarenbcrBa Poccuficroft (De4epaquz l{s842or24.09.2013f,, peA. or28.08.2017 r.).Ha saceAa;g1uv 31Nraq 2018r.Arrccepralll4oHHblft coser [pl4H-ln peIxeHI'IelplrcyArrrb -fr<z\4oeofi Anse OreroeHe yqeHyro creneHbSlrororz.recKl{x HayK no cleIIV€uIbHocTI4llpu03.02.07KaHAHAara- ((reHeTI4Ka)).[poBeAeHulr rafinoro roJrocoBaHI,I.f, Al4ccepraquonnrrfr coBerBno cfleqlraJlbHocrl,I 03'02.07-KoJrr4rrecrne 19 rreJroBeK, r43 Hr{x 8 4oxropoB HayKreHeruKa, yqacrBoBaBllrl{x B 3aaeAaHvrk1 tr3 25 r{eJIoBeK, BXoAITIIHX B cocraBcoBera, nporoJrocoBaJrr4: 3a rrpucyxqeHue yuenofi crerleHl{flpncy)rqflpe4ceHprfle4are JIb- 19, nporr{Byveuoft crerreHrr - Her, ne4eficrwlTeilbHblx 6roueresefiAI,I c cepralll4o HHo roc oBer a[2- uer.I 2 .23 2' I 2AoKTop 6uortorz'IecKllx HaYK,npoQeccop,aKaAeMrar<PAHIrInre-B e.Ironaoe C .f.V.reHrrft ceKperapb AI4ccepraIII4oHHoroKaHALIAaT 6UOlOrUqecKItX HayKfanruna C.A.3I r{an 2018 r..
![](https://s.studizba.com/z.php?f=/templates/si/i/noavatar.png&w=100&h=100&t=1"){kind=avatar}
