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– P. 1-12.136Приложение 1137138139140141142143Приложение 2144145146147148149Приложение 3Таблица 1Исходные данные продуктов интенсивности СРО липидов, белков и показателей активности эндогеннойМалоновыйдиальдегидCO-концевыеостаткиаминокислотБитирозиновыесшивкиОснованияШиффаМетаболитыоксида азотаВитамин ЕБелковые тиолыВостановленныйглутатионОбщаяантиокислит.активностьплазмы крови20,3819,6119,4118,8919,0620,2320,1218,9619,0919,5520,0620,2819,9819,1419,961,3681,3281,4031,4021,3731,3761,3621,3421,3741,3381,4081,3411,4081,3041,3360,450,470,450,460,470,480,450,460,450,480,440,460,450,470,480,290,290,310,300,310,300,290,310,300,310,290,310,300,290,2923,3522,9523,2123,0621,8924,7924,2022,9223,0722,9821,6022,8023,2122,7422,6621,1521,3821,0521,4321,1621,0121,4721,4721,1621,4421,4221,1521,0421,2621,1323,48024,53523,20423,61723,76023,42623,04823,62624,40823,91424,33523,30323,16024,02224,28939,65039,24639,42538,12838,43939,42039,53939,00438,61838,06638,21239,24738,92939,43639,5450,5880,5660,5720,5620,5670,5500,5930,5980,5920,5670,5580,5540,5730,5970,5578,368,668,518,258,568,468,678,518,278,648,438,668,338,328,551,161,151,121,121,111,171,171,111,151,151,151,161,111,161,129,739,669,689,339,89,629,819,679,919,49,419,489,779,579,9АктивностьГлутатионредуктазыКетодиены33,535,835,435,133,333,434,433,133,635,134,033,234,932,933,5АктивностьсупероксиддисмутазыАктивностьглутатионпероксидазыДиеновыеконъюгаты123456789101112131415376,5370,41377,65377,58369,74372,75367,43376,45367,49377,38368,28375,07368,31371,26370,75149№системы антиоксидантной защиты у доноров15035,234,934,735,635,936,434,134,233,435,634,535,235,736,333,934,5719,9420,1420,0019,2519,3819,8819,2919,8319,3420,1919,9919,3318,9319,2719,2419,621,3521,3141,3391,3351,3511,3991,3631,3891,3581,3021,3421,3171,3091,3511,4061,360,480,480,440,440,450,460,460,450,480,450,460,480,480,480,480,460,310,300,290,290,290,300,290,300,450,310,290,290,30,310,310,320,4420,7722,4822,3423,9022,7623,8623,6220,9721,7423,6621,1321,0923,6920,2522,6021,0421,4221,2121,3121,1121,3821,0121,2321,4121,2721,1021,0521,2521,0421,2321,2223,52224,31024,56624,79423,33123,28924,47123,42425,75824,34123,15724,29923,80023,23523,48223,86439,12339,51638,53139,56638,19938,55538,86138,52238,90438,70738,39438,47038,26138,27239,55838,880,5870,5740,5580,5710,5800,5540,5620,5540,5800,5900,5800,5860,5500,5720,5780,5728,258,528,648,418,468,548,568,388,278,678,328,398,448,378,418,461,151,171,151,161,151,131,141,121,131,131,171,141,141,111,101,149,349,749,699,579,839,499,969,89,819,649,599,639,989,699,899,68372,19376,72369,5372,81371,2366,44374,83372,07370,26374,19371,07370,22378,1372,01366,08372,16150161718192021222324252627282930Среднее151МалоновыйдиальдегидCO-концевыеостаткиаминокислотБитирозиновыесшивкиОснованияШиффаМетаболитыоксида азотаВитамин ЕБелковые тиолыВосстановленный глутатион17,7117,6417,6017,8115,4315,5216,1816,3016,9315,8517,7415,5317,8516,0315,1116,4417,3715,6515,9414,941,8601,8131,7381,6112,0391,8001,5471,4122,0011,7831,7571,7552,0751,6521,6841,9771,6861,6521,5191,9020,430,440,440,440,430,460,420,430,440,440,430,430,420,420,440,460,440,430,440,440,350,340,350,340,340,350,360,350,350,360,350,350,360,340,340,340,360,340,350,3633,5734,5633,4533,5433,7834,2934,6133,0134,3734,1435,1035,0633,9335,1333,7935,2433,5433,4133,3235,2623,9124,3724,0724,1724,3724,6924,9024,3424,2724,9924,0724,4424,6224,3524,9625,0824,7025,0124,0425,0820,0823,0822,2420,5823,1822,9722,3120,9219,8722,8820,1723,1022,5220,0523,8622,9921,7223,4420,5420,3026,127,127,426,626,826,426,826,427,225,427,526,326,727,426,625,826,827,527,727,30,2940,3030,3040,2990,3020,3020,3050,3040,2940,3040,3110,2960,2750,2990,3010,3000,3010,2980,3070,3978,688,898,478,548,698,888,928,748,828,958,769,088,818,918,888,629,109,169,108,821,2061,2101,2101,2141,2081,2111,2131,2131,2061,2131,2071,2101,2131,2131,2131,2131,2141,2061,2111,2128,338,498,398,528,458,288,258,688,188,718,388,428,338,498,448,668,668,368,618,31АктивностьГлутатионредуктазыКетодиены43,0443,645,044,643,0843,4545,0743,4344,843,043,6644,445,0145,0744,4145,0843,0344,0743,244,92Общаяантиокислит.активностьплазмы кровиАктивностьсупероксиддисмутазыАктивностьглутатионпероксидазыДиеновыеконъюгаты1234567891011121314151617181920370,0377,9378,6364,3371,1353,7367,1367,1389,7371,5361,5386,6372,8365,4352,2385,7369,7388,8359,1376,6151№Таблица 2Исходные данные продуктов интенсивности СРО липидов, белков и показателей активности эндогенной системыантиоксидантной защиты у пациентов с геморрагическим инсультом15244,5543,643,8544,3345,0244,1743,4244,2543,0745,1143,744,3443,3344,743,0544,144,744,343,044,4144,844,4145,0144,0744,9243,643,6644,3345,0244,643,015,8815,9415,4015,8516,3515,2315,8717,2215,2215,2817,5614,9416,4116,5516,2617,7716,0417,9317,6517,7617,6015,5216,0317,8515,6515,9417,7115,4017,2215,9415,281,9222,0601,4231,8861,9501,7341,5491,7881,8231,6271,4681,9781,6482,0461,4811,8901,7951,5261,4891,3531,7381,4121,6521,9771,8861,8601,7881,8231,7831,9021,6860,420,430,440,440,430,440,440,430,440,430,420,440,430,430,470,450,430,440,430,450,420,440,440,440,440,430,420,430,440,440,430,350,340,350,340,350,360,340,350,340,350,360,360,350,340,350,360,340,340,360,350,360,360,340,360,340,340,340,350,340,350,3533,2233,1434,9633,2733,5633,6733,9033,8333,9134,1034,9134,9233,3233,8034,9933,3134,9734,9834,5734,7833,7835,1033,9333,7934,6133,3233,5433,1434,3734,9633,6724,5324,3324,3124,2724,3724,8924,6324,2724,3525,0424,2024,0624,9524,5024,3324,7524,4324,5924,6724,5624,3724,9924,3524,5323,9124,7024,3124,8924,6324,7624,9021,0921,0922,0520,3323,0921,0022,6822,6923,2621,6522,0220,2220,0522,1723,2122,0919,8920,7821,4723,0120,5522,2622,2919,8521,0720,4921,1920,3222,2023,8422,6525,525,625,626,625,727,727,324,927,126,626,325,825,526,925,928,426,327,427,127,225,927,527,525,826,626,425,827,125,427,325,70,3030,3100,3040,3030,3090,2940,3080,3010,2940,3020,2950,2950,3040,3090,3050,1950,3010,3070,3980,3000,2950,3010,2750,2990,3030,3080,3960,3050,3020,3090,3038,558,519,088,668,568,949,088,528,768,958,918,898,588,878,938,829,189,168,568,768,758,968,698,838,929,118,469,078,838,578,611,2061,2111,2131,2061,2081,2131,2071,2071,2101,2111,2101,2111,2101,2091,2101,2141,2111,2111,2101,2081,2101,2061,2141,2131,2111,2131,2061,2081,2071,2101,2138,198,438,218,498,718,598,338,348,348,158,338,448,688,188,708,418,328,248,308,668,528,338,178,498,448,378,598,368,328,498,15370,7374,8362,3371,8334,3376,7358,2377,1372,8379,8382,9378,4371,7378,9382,7352,4331,8360,9362,9358,9364,3365,4381,7372,8376,6382,7375,8371,8373,1358,2379,115221222324252627282930313233343536373839404142434445464748495051153Среднее43,743,8543,0443,0344,2543,243,0544,445,1143,4244,1745,043,0743,0844,5543,643,044,345,0744,4143,4344,743,4544,743,3344,144,3445,0845,0744,0715,1117,7714,9417,8116,5516,9315,8516,1815,8715,8817,6415,2216,3517,9317,7617,7417,6515,2315,8516,0417,3716,2616,4115,5314,9417,5616,4416,3015,4316,422,0461,7551,4681,6111,9502,0011,8902,0601,6841,7951,6272,0751,5491,6481,8131,4811,5191,7341,5471,5261,7571,4892,0391,4231,9221,3531,9781,6521,8001,740,430,440,460,440,420,440,430,440,440,420,430,440,440,430,440,440,430,440,430,450,440,450,430,460,420,430,440,420,440,440,360,350,360,350,350,340,340,350,340,340,350,360,340,350,350,340,350,360,350,340,360,350,350,350,360,340,340,360,350,3534,2935,2433,8334,1033,5734,9135,0633,3234,9933,4533,9133,2234,5734,9734,7835,1334,9234,9833,3133,0133,8033,2733,4134,1433,5633,9033,5435,2634,5634,124,9424,6824,2724,3324,6924,3724,2724,4224,6224,3424,5424,2724,0724,0624,5124,4425,0124,6025,0824,0724,3425,0425,0824,2024,3524,9624,0424,3724,1724,5123,1022,0322,9922,1423,2220,0719,8823,4622,1121,4820,5720,0820,3223,0022,0620,7622,0822,2720,0820,2120,5221,6622,9323,0122,6722,9123,1023,2922,3021,7725,825,926,726,427,027,226,927,327,225,925,626,426,826,326,825,726,926,525,224,825,925,927,827,127,425,927,824,928,026,480,2930,3020,3040,3050,2950,1960,2970,3000,3970,3020,3080,2930,3010,3020,3100,3110,3000,3050,3040,3000,2950,3100,3030,2930,3010,3090,2960,3060,2980,3039,078,758,948,818,888,659,178,558,959,098,528,928,748,928,838,599,098,538,548,939,158,578,878,769,178,898,888,878,688,831,2101,2061,2141,2131,2111,2101,2101,2081,2131,2061,2101,2121,2111,2111,2131,2101,2091,2131,2111,2061,2131,2081,2111,2101,2071,2111,2131,2071,2141,2108,208,698,458,708,408,288,668,398,248,338,728,338,188,448,338,258,488,308,418,188,678,438,348,618,368,658,728,328,698,42359,1379,8378,9361,5367,1371,7382,7352,2343,.8360,8367,1334,3358,9363,0378,6365,3376,7372,8366,5376,4386,8352,4366,0368,7371,7385,9353,7383,6378,9369,81535253545556575859606162636465666768697071727374757677787980154КетодиеныМалоновыйдиальдегидCO-концевыеостаткиаминокислотБитиразиновыесшивкиОснованияШиффаМетаболитыоксида азотаВитамин ЕБелковые тиолыВосстановленныйглутатионОбщаяантиокислит.активностьплазмы крови40,0239,5540,8040,1040,4039,5439,5640,5040,7840,2639,3239,6939,2139,6639,6340,0240,1940,2839,3539,4424,4822,7018,4624,0121,4918,9518,7919,3318,1020,6821,6620,3118,4618,0618,3421,9619,4820,2122,3820,961,8751,8701,8411,8751,8581,8551,8461,8591,8631,8651,8401,8651,8831,8531,8791,8671,8781,8751,8511,8420,410,390,390,390,390,410,390,390,410,400,410,400,390,390,400,390,400,390,390,410,340,340,360,340,340,360,340,350,350,350,340,340,350,350,340,340,360,360,340,3636,6238,0436,6537,7738,3535,9136,2338,5936,3036,9337,3637,6538,5135,9037,6337,2536,5637,6936,1438,2719,5625,9618,5923,2918,9419,7618,6127,2122,1928,2026,9727,1121,5424,5921,7520,5019,6723,5618,9422,5416,9516,5716,8017,8918,2317,0119,0617,9417,3119,0817,7516,4118,8418,1218,0916,1319,1816,8219,2417,3937,5736,8536,5036,6636,8937,6837,7337,4436,3837,4537,7836,4736,6636,5137,4636,3437,6636,6037,0736,510,4250,4210,4220,4300,4340,4270,4320,4310,4260,4240,4350,4330,4260,4240,4200,4390,4380,4230,4300,4289,228,929,249,339,319,119,029,019,219,118,798,829,119,089,429,029,069,078,829,44АктивностьсупероксиддисмутазыАктивностьглутатионпероксидазыАктивностьГлутатионредуктазыДиеновыеконъюгаты12345678910111213141516171819201,321,311,391,281,231,361,271,221,311,311,331,351,321,301,311,291,281,351,241,2310,6811,3310,3510,2610,9510,9710,5310,9810,1811,0410,1411,2410,4310,8711,1011,1610,1710,8110,9910,13362,06362,87354,72354,37366,90367,69359,28353,55358,60367,38356,19358,01362,46365,48361,25358,10357,57364,75367,16366,02154№Таблица 3Исходные данные продуктов интенсивности СРО липидов, белков и показателей активности эндогенной системыантиоксидантной защиты у пациентов с ишемическим инсультом15540,1439,7440,8239,5739,7839,6340,7040,8339,2740,9540,8240,9640,4140,4840,3439,6440,0340,1740,0040,1440,3440,1439,5540,9640,9540,4139,6339,7440,8339,6639,2119,9224,0519,4422,3422,2320,2621,5522,0123,0220,8723,3123,2421,6723,9623,8721,7019,5121,9922,6422,8823,3122,2321,5522,3819,4418,3419,5118,4619,4818,1023,241,8701,8691,8671,8731,8401,8491,8401,8821,8431,8401,8691,8811,8681,8441,8751,8671,8451,8461,8511,8571,8431,8401,8671,8691,8451,8791,8831,8401,8781,8401,8690,400,400,390,410,390,400,390,400,390,390,410,390,410,410,400,400,510,410,410,510,400,410,390,400,390,400,390,390,410,390,400,360,350,360,340,350,360,360,350,340,350,340,360,340,340,360,360,350,350,350,360,340,350,340,360,340,360,350,340,360,340,3436,2537,5038,2637,5338,1037,6038,3038,6538,1535,8736,9937,5335,1236,8236,9933,6537,5035,2635,9136,9935,1238,1538,3037,5038,2636,1438,1036,5637,3635,9136,3024,3025,0526,9021,9423,7522,0224,1424,9726,3027,4227,6127,0326,0324,0923,1320,6724,0524,0519,0318,9023,1327,6126,3024,1426,0323,7521,9425,0524,0519,6721,7517,4518,3216,8816,7718,6419,1816,8818,6118,6017,7917,8617,2717,2718,9917,4018,4416,4218,9118,4318,2018,3217,7917,3916,1316,4218,0918,6116,4119,0818,4316,7736,5737,6136,1237,2837,1736,2937,4036,8936,4836,6836,6637,7136,1736,9936,2737,0837,6937,2536,5236,2336,6637,1736,4837,4636,2737,4537,0736,1236,8937,6936,500,4300,4290,4310,4270,4290,4250,4310,4300,4320,4380,4340,4310,4260,4250,4240,4270,4290,4320,4290,4280,4300,4320,4250,4280,4380,4310,4270,4390,4340,4320,4259,129,338,719,069,219,279,418,839,139,099,088,858,839,278,849,199,069,259,209,098,969,129,089,069,278,849,358,749,169,098,621,351,331,281,261,331,271,311,361,341,421,261,311,221,341,341,271,251,331,371,441,261,221,281,251,301,231,331,311,291,271,2810,4510,2110,9010,5311,2710,6410,9510,3411,0610,1410,9512,0010,6110,6011,2210,2010,4410,6010,4510,7910,6110,9511,0611,2210,9510,2110,4410,9910,9011,0410,87367,27364,00355,36356,63359,24366,41357,29357,32364,24358,25359,20355,18364,83367,19354,31362,82360,68359,54356,25356,52364,24359,20367,27366,02354,31356,19357,29358,60360,68367,16366,9015521222324252627282930313233343536373839404142434445464748495051156Среднее39,3539,6340,1940,5039,5440,7840,8039,5639,3240,1040,0240,4040,1439,6940,2639,4439,2740,8240,0240,0340,4839,5740,8340,0040,2839,7840,8239,6440,1740,06721,6621,4919,9224,0123,0218,4618,7920,9618,9520,8721,9621,7018,0621,6720,6822,7020,3119,3320,2624,0524,4820,2122,8822,3422,0123,9623,8722,6421,9921,251,8631,8551,8491,8681,8461,8511,8581,8441,8701,8751,8511,8751,8591,8731,8411,8821,8571,8651,8421,8751,8461,8671,8651,8671,8531,8701,8811,8401,8751,8600,390,390,400,400,410,390,390,410,400,400,410,410,390,510,410,390,390,390,410,390,400,400,390,410,510,410,390,390,410,400,350,350,340,340,340,350,340,350,350,360,340,360,350,340,350,360,350,340,350,360,340,360,360,350,360,360,360,340,360,3537,6336,6536,9936,6237,6536,9938,0437,2537,5336,2335,2635,9136,2538,2736,9336,9937,7738,3538,5935,8738,5137,6035,9037,5337,6938,6537,5036,8233,6537,0819,0327,1118,6122,0218,9422,1927,0318,9423,2924,9719,5621,5420,5026,9718,9025,9619,7624,3018,5927,2124,0522,5428,2027,4224,0924,5923,5626,9020,6723,2719,2416,8817,3118,9117,0118,6017,8917,2716,8016,5718,1219,1816,9517,4018,2316,8819,0617,9418,9917,7518,8417,8619,1818,4418,6416,8217,2717,4518,2017,8336,8936,3437,5736,5736,8536,2337,4436,6636,9936,6636,4736,5137,0837,6836,6037,7337,2537,7836,3837,7136,2937,6636,5236,5137,6136,6837,4036,1737,2836,930,4300,4260,4310,4260,4240,4270,4310,4230,4290,4280,4240,4300,4290,4210,430,4250,4260,4380,4330,4320,4290,4300,4220,4290,4200,4340,4270,4350,4240,4289,409,068,869,099,018,659,239,419,079,399,139,169,308,928,859,349,268,839,179,099,239,018,599,288,579,058,859,099,129,081,231,271,231,291,341,271,341,341,431,361,281,371,251,311,311,321,311,281,331,421,311,241,351,371,311,351,341,321,361,3110,2410,4510,8110,1810,9511,2710,5310,3510,1310,6810,6011,3310,1412,0010,2611,1610,9710,2010,9811,0410,1410,4310,6011,1010,7910,1710,4510,6410,5310,71357,57350,72359,54367,69365,48355,36362,06359,24367,38358,10361,25356,25362,46359,28356,41362,87355,18354,37356,63353,55362,82358,01364,75356,52364,00364,83357,32358,25367,19360,51565253545556575859606162636465666768697071727374757677787980.