Диссертация (1145883), страница 36

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sfp1Δ / Isp+ , снижение экспрессии: metabolic process (GO:0008152), nucleobase-containingcompound transport (GO:0015931), methylation (GO:0032259), cellular component biogenesis(GO:0044085), regulation of cellular amide metabolic process (GO:0034248), biosyntheticprocess (GO:0009058), organic substance metabolic process (GO:0071704), nitrogen compoundmetabolic process (GO:0006807), primary metabolic process (GO:0044238), cellular metabolicprocess (GO:0044237), RNA secondary structure unwinding (GO:0010501), amino acid activation(GO:0043038), cytoplasmic translation (GO:0002181), organic cyclic compound metabolic process(GO:1901360), ribose phosphate biosynthetic process (GO:0046390), polyadenylation-dependentRNA catabolic process (GO:0043633), RNA 5’-end processing (GO:0000966), transcription fromRNA polymerase I promoter (GO:0006360), cellular aromatic compound metabolic process(GO:0006725), ribonucleoprotein complex localization (GO:0071166), nucleic acid phosphodiesterbond hydrolysis (GO:0090305), snRNA metabolic process (GO:0016073), small moleculemetabolic process (GO:0044281), organonitrogen compound metabolic process (GO:1901564),posttranscriptional regulation of gene expression (GO:0010608), nucleobase biosynthetic process(GO:0046112), heterocycle metabolic process (GO:0046483), gene expression (GO:0010467), ncRNA5’-end processing (GO:0034471), RNA phosphodiester bond hydrolysis (GO:0090501), singleorganism biosynthetic process (GO:0044711), organic acid metabolic process (GO:0006082),187translational initiation (GO:0006413), organonitrogen compound biosynthetic process (GO:1901566),ncRNA 3’-end processing (GO:0043628), tRNA transcription from RNA polymerase IIIpromoter (GO:0042797), establishment of ribosome localization (GO:0033753), tRNA transcription(GO:0009304), maturation of SSU-rRNA (GO:0030490).4.

sfp1Δ / Isp– , повышение экспрессии: catabolic process (GO:0009056), response to external stimulus(GO:0009605), monosaccharide transport (GO:0015749), single-organism process (GO:0044699),response to stimulus (GO:0050896), cell wall organization or biogenesis (GO:0071554), fungaltype cell wall organization or biogenesis (GO:0071852), generation of precursor metabolites andenergy (GO:0006091), cellular carbohydrate metabolic process (GO:0044262), cellular respiration(GO:0045333), carbohydrate metabolic process (GO:0005975), single-organism metabolic process(GO:0044710), monocarboxylic acid metabolic process (GO:0032787), oxidation-reduction process(GO:0055114), single-organism cellular process (GO:0044763), small molecule metabolic process(GO:0044281), organic acid metabolic process (GO:0006082).5.

sfp1Δ / Isp– , снижение экспрессии: metabolic process (GO:0008152), RNA secondary structureunwinding (GO:0010501), establishment of ribosome localization (GO:0033753), organic substancemetabolic process (GO:0071704), ribonucleoprotein complex subunit organization (GO:0071826),biosynthetic process (GO:0009058), nitrogen compound metabolic process (GO:0006807), primarymetabolic process (GO:0044238), cellular metabolic process (GO:0044237), amino acid activation(GO:0043038), cytoplasmic translation (GO:0002181), organic cyclic compound metabolic process(GO:1901360), cell cycle DNA replication (GO:0044786), transcription from RNA polymeraseI promoter (GO:0006360), RNA 5’-end processing (GO:0000966), cellular aromatic compoundmetabolic process (GO:0006725), small molecule metabolic process (GO:0044281), nucleicacid phosphodiester bond hydrolysis (GO:0090305), organonitrogen compound metabolic process(GO:1901564), heterocycle metabolic process (GO:0046483), ribonucleoside monophosphatebiosynthetic process (GO:0009156), ncRNA 5’-end processing (GO:0034471), gene expression(GO:0010467), RNA phosphodiester bond hydrolysis (GO:0090501), maturation of SSUrRNA (GO:0030490), single-organism biosynthetic process (GO:0044711), translational initiation(GO:0006413), organic acid metabolic process (GO:0006082), organonitrogen compound biosyntheticprocess (GO:1901566).188Приложение ДРезультаты сравнительной геномной гибридизации (aCGH)Представлено графическое обобщение результатов гибридизации геномной ДНК с ДНК-микрочипом.

В заголовке каждой части рисунка перечисленыклоны-источники опытной и контрольной ДНК для гибридизации. Хромосомыпредставлены по порядку сверху вниз. Нижний (17-й) ряд — контрольные последовательности и рДНК. Красным цветом отмечены участки с повышеннойкопийностью, зелёным — с пониженной копийностью.А.

25-2В-П3982 vs PSL2Б. p1 (Isp+) vs PSL2В. m1 (Isp–) vs PSL2Г. p3 (Isp–) vs PSL2189Д. m2 (Isp–) vs PSL2Е. p4 (Isp+) vs p1 (Isp+)Ж. p14 (Isp+) vs p1 (Isp+)З. p10 (Isp+) vs p1 (Isp+)190И. p12 (Isp+) vs p1 (Isp+)К. p13 (Isp+) vs p1 (Isp+)М. p11 (Isp+) vs p1 (Isp+)Н. m4 (Isp–) vs p1 (Isp+)191О. m7 (Isp–) vs p1 (Isp+)Р. m9 (Isp–) vs p1 (Isp+)П. m8 (Isp–) vs p1 (Isp+)С. m11 (Isp–) vs p1 (Isp+)192Т.

P-2В-П3982 vs PSL2У. 2-P-2В-П3982 vs PSL2Ф. sfp1Δ-1Б-Д1606 vs PSL2Х. sfp1Δ-25-25-2В-П3982 vs PSL2193.

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