Отзыв официального оппонента 3 (Функциональная гетерогенность Na,K-АТФазы в скелетной мышце)
Описание файла
Файл "Отзыв официального оппонента 3" внутри архива находится в папке "Функциональная гетерогенность Na,K-АТФазы в скелетной мышце". PDF-файл из архива "Функциональная гетерогенность Na,K-АТФазы в скелетной мышце", который расположен в категории "". Всё это находится в предмете "биология" из Аспирантура и докторантура, которые можно найти в файловом архиве СПбГУ. Не смотря на прямую связь этого архива с СПбГУ, его также можно найти и в других разделах. , а ещё этот архив представляет собой докторскую диссертацию, поэтому ещё представлен в разделе всех диссертаций на соискание учёной степени доктора биологических наук.
Просмотр PDF-файла онлайн
Текст из PDF
OT3hIBo$uquanrHofo orIrIoHeHTa Ha Al4cceprarlr4ro Kpanqoeoil Bzolerrn Baculr,eBHbr( OyHKI-\I4 OHAIIbHAI f ETEP O f EHHO C Tb Na,K-ATO as u B C KEJIETH OIZMbIIIIUE)), rrpeAcraBneHHyro K 3aqr{Te Ha corrcKaHr4e yrreHofi creueHr,r AoKTopa6zororu.recKl4x HayK rlo cneu[aJrbHocrr4 03 03 0 1 - SzsraoJrorr4.rr..Alcrya"rrtnocr[, TeMbI rIccJIeAoBaHuqCorparzreJlbHatl aKTIrBHocrb cKeJrernoft MycKyJrarypbr, Macca r<oropoficocraBJlf,er oKoJIo 40%orBcefi Maccbl TeJra, rBJr-rrerc,flI4cKJrroqt4TeJrbHo Bax(HF,rMSar<roporra o6ecne.renlafl [oJrHorleHHoro Syur<qraouvrpoBalLrs Bcex cr4creM opfaHr43Ma.Csvxceuze ABrlfareJlbnofi axruBHocrz rrpt4BoArrr K yMeHrrrreHr4ro MhrrrleqHofi ruaccu,coKparl'ITelsuofi 4ucQynxqwvg;pyrl4M MHoroqr4creHHbrM HapyueHtrflM arpoSzvecKofoxapaKTepa, Moner<yn-flpHble MexaHI43MbI, Jrer(ailIue B ocHoBe raKr4x HapyilreHr4fi, nr<lrouaxI4X HaqaJlbHbre 3TafIbI, KoTOpbIe MOfyT r4fpaTb poJrb Tpr4ffepoB AJrr rrocJreAyrcllluxcIrfHaJIbHbIxco6rrrufi, nusunarorlzx arpo$uro, Bo MHoroM ocrarorcrHercHbrrvru, BqacrHocrl4, 6olr,ruofi [paKTI4qecr<ufi zurepgc Bbl3brBaer I43yqeHr4e nycKoBofo MexaHr43Mapa3Burkrfl MblllrerrHoft arpo$ul4 B ycJloBt4tx peiurbuoit ttt MoAeJrr{pyeuofi HeBecoMocrra.
BcBt3I4c orI4M HecryqaeHBI4AHoI4cKrloqr4TeJrbHovI3 ofpoMHoroKoJII4rIecrBasrrcoxzfir,rHTepecrAansoft npo6leue, rrrony6rnraqufi, frocBtqeHHblxQyunqzonvpoBaHvfl cKeJIerHbIX Mbrrrrq B HopMe14MexaHr43MaMnpv pa3JrrrqHbrx QopnraxHapyureHr4.sABr4rareJrbuofi ar<rraeHocrr4.Cpe4ra MexaHI43MoB rloAAepxaHr{r gJreKTporeHe3a, aos6ygzuocrucoKparlrrelrnofi Synrcqrzu cKeJlerHbrx MbrrrrqKpt4Tr4qecKr4 Ba)KHhrM$axropovr rBrf,grcqaKTI4BHocrr Na,K-AT(Dasr'I. @raslaorou4qecKa.f, poJrr, Na,K-AT@asHMbIIXqaXtBJlterctBcKeJrerHbrxrIpeAMeToM rrHTeHcr4BHofO Vr3ylse}lvfl, Koropoe cepbe3Ho ocJrolr(HeHoHe roJIbKo cyuecrBoBaHveM pa3rr4rrHbrx MoJreKyr-f,pHbrx$opr orofo6elxa, Ho rarcKe Lrx cneqnQzvecroft uenr6panHofi loxallusaqzeft,peryJItIII4I4 kr B3al,IMoAei4crsvxtBJlterct14crIoI4crI4He BI4TaJIbHbrMMoJreKyJr-rrpHbrM oKpy)KeHr4eM.rpaHcnoprHorooco6euuoc-tsMr4XorqNa,K-ATOa^:a6elxou, upo6lenra zso$opu-cueqnozvHocrr4$yurqIaoHzpoBaHl4t B cKeJlerHofi urnuqe AaJreKa or'pe*rrreHvs.3HarIeHI4e aKTrIBHocrb Na,K-ATOa^rrrB qacrHocrr4,l4Meer 1^ilfl rroAAep)r(aHr4reeoco6oe3JreKTpofeHg3arlocrcl4HarlTz.recKofi o6lacru MblrrlerrHofi vrerra6paHbr, rAe rrpor4cxoArar rpaucsopMarltuJIoKaJIbHofo fIoreHIII4aJIa rcouqenofi flnacrr4HKrrB paclpocrpau'|rotsluitcn[oreHUI4aJr2AeficrBr4r, rrro olpeAeJrrer HaAeNCHocrb HepBHo-MbIIIreqHofi nepe4aupl B ueJIoM.
OAsarouoco6ennocru JroKrurpr3aUr{rl, QynnqraoHvrpoBaHkrflMoreKyr-f,pHblx esavlaoAeftcrrvfrNa,K-ATOa3br B erofi o6nacrr.r capKoJreMMbr He I4ccJIeAoBaHbI. llepcnexu{BHblMl4AJLf,Aarrseftruero r43yqeuur usoQopM-creql4QIauuocrv $ynrqnonlapoBannfl Na,K-ATOa3bIcrelersofi Mbrrrrqe rapr(e rrBrrrlorctBSKcrIepI4MeHTaJIbHEIe MoAeJII4 uapyurenrafi4nurarelrHofi aKTr{BHocrr4, [pr4BoAqilI[e Kpa3BI4TZro pa3rI4qHLIX$opuMvrorrurvLi.)lpr4r{eM oco6rrft r4HTepec [peAcraBJlter naqalr,ur,rft STaI] AslararemHoft pa3fpy3Kl4,rBHo HeAocraroqHo. Bancsoil upo6nevrofi f,BJrqerctr4ccJre.rloBannuficQyurqraoH4JrbHoro B3ar{MoAeftctsvrfl. Na,K-ATOa^:rrnpaKT[qecKr4HecJro)Kr{Jracb r{ BrrccJleAoBaHHoroBI43yqeHuerraeu6paHHblM xoJrecrepl4HoM,cr<elernofi MbIIxue. Anaroruqna.fl cr4Tyawrflo6lacru u3yrreHr4r sQQexron 1zrfvralrvcouoAo6srrx uurn6uropon Na,K-AT@asu rr I4x III4pKyJIrrpyrcuI4x 3FIAoreHHbIx aHaJIoroB.B csrs1a c gTr,rM, Ar4ccgprarlr4oHHoe l4ccJleAoBanue B.B.
Kpanqonofi, uoce{ueHHoeKoMrUreKcHoMy rroAxoAy K perrreHl4rc uepequcJleHHblx npo6leu, a TaKxe ptAa Apyrl{xrrpr4Hur4rrr4ifJrbHoBaxHbrx BorrpocoB, 6eayclonHo, trBilflercfl. BecbMa aKTyanbHr,IMcepbe3Ho rrpoABr4raer Harrrr4 3HaHIrtB o6lacrvvlMoJIeKyJI-trpHbIX MexaHI43MoBIrJracrl4qHocrl4 cKeJleruoft MLIuqbI.HayunaaHoBrr3Ha r{ccJreAoB anrrs. rd HayqHo-[paKTuqecKaq 3HaqlrMocr[,rIoJryqeIrHblx pe3yJrbTaroBHonzsua Aannofi pa6oru Bo MHoroM orlpeAeJlnerct KoMfIJIeKcHbIM rIoAXoAoMr4ccJreAoBanraro Synr<rlrroHaJrbHoro pa3Hoo6pazut.Na,K-ATOa3bI B crelernofi Mr,Itrrqe cucrorrb3oBaHr4eM rrrupoKoro apceHarra caMbIX coBpeMeHHbIX MeroAoBToJIr,Ko enexrpoQr43r4oJloruqecKr4e r{ccJreAoBaHnfl,TexHr4Kr4 14eroAc14rIoAXoAoB.3ro nenpI4MeHeHI4eM Ml4Kposlexrpo4uoftMexaHorpaSux, Ho raK)r(e MeroAbr LIMMyHoIII4ToxI4MI{I4 Ia xouSor<ansHoilMr4KpocKofrr{r4, Mero4MKIIJI aM eHHlI[P B per(uMe peaJlbHofoBpeMeHI4 Iaofi $ orolre rpvrr4, Q aprvr axon orraq e cr<ufiK TIpI4opIITeTHbIM pe3ynbTaTaMBecrepH-6loraHaIrr43,aHalrr43 .TngCEPTA\UVICJIEAYET OTHECTI4 BfIEPB6IE^noryqgHHbre aBTopoM y6e4rarelurr,re AoKa3areJlbcrBa cneqz$nr<z JIoKaJIIr3auI4I4 a2usoQopv6r Na,K-ATOasbr Lr ee SyHrcqr4oHaJlbHoro B3avMo[ei4ctsvrxxoJrr4HopeuerrropaMrazrueu6paHHbrM xonecrepvnou.sBrrerct ocHosofi Sra:uolorl4rrecKofocHI4KorI4HoBrIMI4BarHo, rrro 3To B3al4MoAefrcreneMexaHI43Ma [oAAep]KaH[q noreHIII4aJIa rloKotJloorcr4Halrr4qecKofi MeM6paHbr.
Anropona ycraHoBJIeHbI oco6enuocru srl4xMe)r(MoJreKyJrflpHbrx B3ar{MoAeficrsvfi,vt rloKa3aHo, qro r<ouSopvrauuonnrrfi nepexoAHr,rKoTLrHOBbrX XOJrr4HOpeqerrTOpoBMoAyJrr4pyrorur4M crzfHaJroM[rrflB cocTotHI4eAoOeHOIITI43AI\W flBIIfleTCflcr2-u:oQopvrrr Na,K-AT@a:u.
Bnepnrre floryqeHblAoKa3areJrbcrBa perlr4rrpoKHoro B3ar4MoAeftcrsz-s Mer(Ay cx,2-zsoSopruoit14xoJlecrepl4HoMJrrrrprAHbrx rrJrorr,rKoB (p aQron).KsaxHefirrrr4M orHocrrcr raKx(e AoKa3areJlbcrBaroro, tITo KparKoBpeMeHuoecHIDr(eHI4e ABl,IfareJrbuofi axruBHocrr4 rro-pa3HoMy BiII4.[erBHecr4Harrrr4.recKr4fi [yJrbr cx,2-nsoQopurr Na,K-AT@a^sH 6esB capKoJrel,rrue.xapaKTepu3ruHa rlocrcrlHarlTl4qecxuittvtnapyuresvs ee JIoKaJII43aIII4II$yur<quonzlJrbHbre rr3MeHeHI4x u2-ttso|opMr,I Hocqr aAarlTaurlossuftcoilpoBolKAarorcfl p-rrAoM crpyKrypHo-$yHr<qzoHaJlbHblx repecrpoeK. BqacrHocrt4, na6lroAaerc.rr Aecra6urza\vtfl. ilvrtun-yrtoptAorreHsoft Qa:rr capKoJIeMMbI 3acrrer qacrz.rHofi yrparbr lrena6panHoro xoJrecreprzHa; Hapynaerct crpyKTypa KoHIIeBbIXrrJracrr4HoK"Bueperre rroKa3aHo, 'aro a2-vzoSoplra Na,K-AT@a3bI Mo)I(er yqacrBoBarbpefyJrfrlr4r4 coKparrzreltuoft Synr<qun cr<erernofi MbIIIrubIBoHAoTeHHLIMI4KapArroroHr4qecKr4Mrr crep OI4AaMI,I.Haroneq, npoBeAeHsrrfi xoruuerccnrrfraHaJrv3 rro3BoJrrrJr aBTopy cAeJlarb BbIBoA oSyrucqzonalrnof rrJracrr4rruocrrl cr2-usoSopvrrr Na,K-ATOasrI rlo cpaBHeHVro cSyurquoHaJrbHo cra6zlr,uofi crl-vsoQopuoft, qro rBJr{erc-tr KpylHbIM AocrIDKeHI4eM Bsroft o6racrz SusnoJrorrzr4,Heo6xoAzMo [oAqepKHyrb, rrro 3Haqr4Mocrb erofi pa6orbl He orpaHzql4BaeraflloryrreHr4euSyn4aMeHTzLJrbHhrx 3HaHrrfioiuoreKyr-spHblx nepecrpofrKax B npoqeccea;:anrar\w flocrypaJrbnoft lrrrruqbr K rpaBrrraUr4oHHofi pa:rpy:KeB ycJIoBI4tx peanbluoitttMoAeJrr4pyeuoft HeBecoMocrn.
O6nacrr, rrpr4MeHeHlr-f, [olryqeHHblx AaHHLIX 3HaqI4TeJIbHorrrr4pe, [ocKoJrbKy BbrrBJreHr4e MoJreKyJr-trpHbrx MexaHr43MosroAo6Hrrx $ynr<qI4oHaJIbHbIXHapyrreHr4fi orxprrnaer HoBbre [epcrreKTr4Bbr. rrpu nor4cKe MeroAoBIrxKoppeKUI4I414npoQranarcrrarz, npo6JreM, r4cKJrrorII4TeJrbHo nocrpe6oBaHHbrx He roJIrKo B KocMl4qecxofi,Ho14Bpea6urzraquonnofiMeAIIIII4He.Tar<uu o6pa:onr, HoBr43Ha vr HayqHo-[paKTrrqecKar rleHHocrb [oryqeHHbrxaBTOpOM 3KC[epI4MeHTaJIbHbIX AaHHrIX He Bbr3blBaror COnrUenrafr"4CreueHr o6ocHonaHHocrlr HayqHbIX rroJrolr(eHr,rfi, percoiuenAarlufi Ir BbrBoAoB,cQoplry.nllpo BaHHbrx B Aucceprarlr{HPesylrrarrr3KcrIepI4MeHToBMarepvilJl o6ruzpenBce14xoporuoAoKyMeHTr4poBaHhr, r{JrJtocrparransuficBLrAergJlbcrByer o BbrcoKoM KaqecrBe [oryqeHHhrx pe3yirbraroB.I4cxoAHbIe AaHHbIe rruarenbHo o6pa6orauuaHalrvr3y.
O6cyx<4euIaevvrroABeprHyrbr pa3HocropoHHeMyoIIeHKa co6crnennrrx pe3yJrBTaroB rrpoBeAeHbr aBTopoMKoppeKTHo 14 He BbI3bIBarcT Bo3palr(eHuit.pa3rl4rlHble BapI4aHTbI TpaKToBoKcflpt't o6cyx<4enrrv pe3yJrbraroBrrpr4BrerreHr4eMpaccMorpeHbro6lrzpHoro cnr4cKa ny6lunaqvrit no4auuofi npo6leue. Crarzcu4qecKaq o6pa6orra .qaHHr,rx [por43BeAeHanoMotrlbro[pofpaMM.aAeKBaTHr,rx coBpeMeHHr,rxPe:ylrrarblcAl4cceprallrIoHHoro r4ccJrelosaHvsvB.B. KpanqonofiloJro)KeHbr HaB ToM rrr4cJreMe)IqyHapoAHLIX. llo reMe AI4ccepraUI4I4 ouy6luronauo 25 cra'reft B r4s1a14flx,MHororII4cJIeHHhIX cbe3Aax, cl4Mrlo3r4yMaxpeKoMeHAoBaHHbIXnonlpepeHrJkrflx,BAK P@, vI: Koropblx 20 exoAqr B Me)KAyHapoAHbre6a^:rr Hayr{HofoIII4rrIpoBaHur Web of Science Core Collection u Scopus; 5 crarefi B Apyrr{x r431aHtrflx.Yqzrrrsas o6Iurzpnuft oKcrlepl4Menranrnrrfi Mutepr4arr,ypoBeHb I4ccJleAoBaruvrftua]F'aJrkrsape3yJrbraron, anpo6auuro6olrruort r{r4cre oreqecrBeHHblx krcav^stfr, conpeveunufipa6oru Ha AocraroqHoMe)rqyHapoAHbrx HayrrHbrx co6pauvft.HoBr43HavccJleAoBaurTfl, vt AocroBepHocrb BbrBoAoB He BBI3hIBaer Hr4KaKI4x corranenzfi.OqeHna coAepr(aHrrfl Arrccepraur.rrllvcceptatyux [ocrpoeHa rlo rpaAr4ur4oHHoMy rrpr4Hrlzny ar43Jro)r(eHasa236crpaHI4llax MaIrrI4HorII4cHoro TeKcTa.
