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Comparative study of the efficiency of Hp eradication revealed that in patients of the assessed group the eradication index has reached as high as 86.7 % as compared to the control group with the Hp eradication index of 76.5 %.

Analysis of existence and incidence of adverse effects caused by the administered preparations in both groups, has shown that incidence and severity of adverse effects induced by the drugs, included into the eradication scheme, was considerably lower in the assessed (18.3 %) than in the controls (41.5 %).

Results of the investigation of cardiac rhythm variability have displayed a more pronounced improvement of variability parameters in the assessed group as compared to the controls and these indexes are evidence of a higher efficacy of therapy administered for the former. The share of low-frequency oscillations decreased and, correspondingly, the share of high-frequency oscillations increased, vegetative balance normalized and effect of central humoro-metabolic factors on the regulation of cardiac rhythm reduced.

Beneficial therapeutic effect of Flurenizide on the metabolic processes and status of the regulatory systems of the organism is due to antioxidant and antiradical properties of the preparation. It has also to be mentioned that Flurenizide as a biologically active preparation effects the cellular and humoral links of immunity due to its immunomodulating properties, and inclusion of Flurenizide into the complex treatment of Hp-associated ulcerative diseases normalizes immune homeostasis and thereby increases the efficacy of therapy.

Complete remission achieved in the assessed group was in total 96.6 % and eradication of Hp infection – 86.7 % cases. In the control group, remission of the disease has been clinically observed in 90.8 % and Hp eradication – in 78.5 %.

Carried out investigation enables improvement of the preciseness of diagnosis and efficacy of treatment for ulcerative disease of the duodenum associated with Helicobacter pylori.

Key words: duodenal ulcer disease, Helicobacter pylori, treatment, heart rate variability, Flurenizide.

ПЕРЕЛІК УМОВНИХ СКОРОЧЕНЬ

ВНС – веґетативна нервова система

ВСР – варіабельність серцевого ритму

ВХ – виразкова хвороба

ДПК – дванадцятипала кишка

ЕҐДФС –езофаґоґастродуоденофіброскопія

ФІ – функціональний інтервал

HF – high frequency (укр.: коливання високої частоти)

Hp – Helicobacter pylori

LF – low frequency (укр.: коливання низької частоти)

pNN 50% – відсоток пар сусідніх кардіоциклів, які відрізняються більше ніж на 50 мс

SDNN – стандартне відхилення середньої величини RR інтервалу

TP – total power (укр.: загальна спектральна потужність)

VLF – very low frequency (укр.: коливання дуже низької частоти)

Характеристики

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