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However, they can have distinct locations in a cell and perform subtly different functions. As a striking example, a specific form of 0ltubulin forms themicrotubules in six specialized touch-sensitive neurons in the nematodeCaenorhabditis elegans.Mutations that eliminate this protein result in the loss oftouch-sensitivity, with no apparent defect in other functions.Figure 16-17 Direct observationof thedynamicinstabilityof microtubulesin aliving cell.<AAAT>Microtubulesin anewt lung epithelialcellwereobservedafterthe cellwasinjectedwith a smalla m o u n to f r h o d a m i n lea b e l e dt u b u l i na, sin Figure16-15.
Noticethe dynamicinstabilityof microtubulesat the edgeofthe cell.Fourindividualmicrotubulesarehighlightedfor clarity;eachof theseshowsalternatingshrinkageand growth.(Courtesyof WendyC.Salmonand ClareWaterman-Storer.)('t66t 'ssardAroteroqelroqreH6uuds plo):AN iroq.reH'g'1''a;6u1166urrd5p;o1 'fspa'sauof'trtr'3'qreorB'U'fl salworDtp)Ds$e4\aql Jo^6010rgrplnllal puereln)aloryeqf ur "le la uralslog'C urotJpoldepv)'^al aq] ur pale)rpursplolo) aLuesaql u! uMoqsa.ressa)ororelnlla)erlulauresaql ur alelado leql suralo.rdl.rossarry'aotsAatat sattrwd Dtp) oSlseol aqt ur 'senbruq:a}le)rLlaq)orqro rrleua6.raqlla6ursn'palerlsuotuapuaoqe^eqteql suorl)eralulaql Jolsou.rsr*oqsuerberpsrql's1;a>>r1ofue>na;1eur suralordftossal:ejo,{lalrena6.re;,(rane ol spurqur})V'spporssor)aql u!l)V glet-9 t arn6rllaqloli1l'srso1,{:opue'uol}ar)assutso{tus r s a q l u { sp r d r l{ 1 u e 1 o d' 6 u r p p n q' u o r s r ^ r plle)s r r u - r e u r}{upa u e l r }:1:l)a{eru lEqt (sel{corpuepoS[o pallEr) slle3 IPI6 pezllBlJeds aqJ 'ed,4fIIeo ,{ra^e'stuslue8Joaseql ulJo rusEldol,{Jeq} ul peJrnbal lou eJEsluauPlrJ elErpeuJeluue^g '$lsn[ou puE 'sapolerueu 'sa]eJqaue^ Sutpnlcut-suBozelelu eluos .{Iuorn lua[rrelu f,rursEldils e suJoJ '1uauru\yfarylpawJalu eq] 'ula]oJdIP]ale{soil.c'ulnqnt pue urtJp urptuoJ sllec clto[rerneIIVJo ed,q ro[eru prlq] aqt lngpuPslro) pallo),o burlsr/vrl6u;;punglerale'laqt uo spuedeqarnt)nrlslueueltl ele!pautolul'peelsur sJeuued Surpurq Jreql JellB ol pue 'auole ullnqn] pue uI13Pe^eal ol elqelrJoJd aJoru ]r punoJ e^eq susrueSJo Suvrlona 'arurl JeAo 'elrs eurBsaql reau Jo ]E purq leql suraloJd Jeqlo qll^\ suollceJalul sll uI seSuBq3elqeJls-apun asnBs1q3$r uralord auo qlur uorlJBJelul slr uI aSuPqJelquJrsepP ur llnsaJplnoJ lpql ullJe ur uopulmu.{ue 'snql'(gt-gf arntlg) eJouruale qllm^llceJlpulpup 'suraloJd raqlo Jo suazop q4rlt fllJeJrp slJeJalur urlcu lpqt peleJlsuouepa^etl aarclnalal saJ/tutoJDtlJJas$ee1\ eql q sarpn]s lEcruaqcorq pue Jr]auac'salntJnJls JraqlJo &g11qerre,reql slluI elnqnloJJlru Jo tuatuellJ UIIJE uB JoaJeJJnsalrlua aqt qll^\ ]cEJelur 01 suraloJd Jeqlo Jo sJaqrunu a3re1ro3 peeu aql(urlnqn} Jo ur}f,e ol pulq}eq1suralord rtrosleq] sl uorleueldxa,{1a4t aql;rou aJE-seJJBJo serFruEJa3re1aql pue surelord ]ualuulrJ elErpaurelul SuIpnlJuI 'sulel-ord pla1a1so1dcraqlo lsoru Jo sacuenbaseql seaJeq^ 'uorlnlona JllodJef,nauIpa^JasuoJ ,{1}cr.rlsos uqnqn} puE urlJB Jo seJuenbas prse ourue eql aJP^r{ru,(g o1 alqeun sl lnq IBr.uJou$lool leq] ,(U e uI s]lnsal apqdosotg ut uI]cB ]sea^;o uorssardxeeql le,{'leor}uapr oh61an ur}oe alosnruapqdosotq pue urloe lsee1'sllac alcsnuuou'slleJ el3snru urIp lsorule ur raqtaSol punoJ eJEl, pue fl alrqmfpo passardxesI upoe-n eql 'seJuanbasprce ourrue Jraq] ut.{11q8rtsJagrp }pq}t pue '$ 'lr paruJel 'urlJp Jo sruJoJosrlueJeJJrp-{1fqnseerq} eJBaJaq} 'saleJqeueluI 'seouaJeJJrpIeuorlJunJ luergru8rs asner ueJ eouenbes prop ourup urlop ursuorlerJel llerus 'urlnqn] a>1r1urc3e ']ng 'pcrluapr %06 ]noqp rtlensn a.resareads'salo^,(rucnaSuoure pe^JeslueraJJrpruorJ surlJe;o sacuanbas prJp ourrue aq;-uoJ lla-,vrdpeurproerlxa sr upcv 'xrs a^Eq sueunq luqce Surpocua saua8 aldp-lnru aleq srusrue8ro lsohtr 's11accrlol.recna ile ur punoJ sr urloe 'ugnqru a{r'I€86tvrttl)sol^) Jo tunDnuis )twvN^ocNVAtSt/\llssv-JltsslNtt^Jv-ilrlHtl u a u e l r ] a ) r l a o o Je o l u r p a l s r M ]s j a u r e j l e ll q D r ereqla6ol pa1:ed srauetlal om1(a)rrllsJaurp lro)-pepo)oml ]o rauella) pata66elsHOO)HOO)ZHN()),TIZHNuu 8? ----------------fzHN.
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