B. Alberts, A. Johnson, J. Lewis и др. - Molecular Biology of The Cell (6th edition), страница 3

For the correspondinggene names in all these cases, we shall nevertheless follow our standard rule:Actin, Hemoglobin, Catalase, Bmp4, Gfp. Occasionally in our book we need tohighlight a protein name by setting it in italics for emphasis; the intention willgenerally be clear from the context.For those who wish to know them, the table below shows some of the officialconventions for individual species—conventions that we shall mostly violate inthis book, in the manner shown.Species-Specific ConventionUnified Convention Used in This BookOrganismGeneProteinGeneProteinMouseHoxa4Hoxa4HoxA4HoxA4Bmp4BMP4Bmp4BMP4integrin α-1, Itgα1integrin α1Integrin α1, Itgα1integrin α1HumanHOXA4HOXA4HoxA4HoxA4Zebrafishcyclops, cycCyclops, CycCyclops, CycCyclops, CycCaenorhabditisunc-6UNC-6Unc6Unc6Drosophilasevenless, sev (namedafter recessive phenotype)Sevenless, SEVSevenless, SevSevenless, SevDeformed, Dfd (namedafter dominant mutantphenotype)Deformed, DFDDeformed, DfdDeformed, DfdSaccharomyces cerevisiae(budding yeast)CDC28Cdc28, Cdc28pCdc28Cdc28Schizosaccharomycespombe (fission yeast)Cdc2Cdc2, Cdc2pCdc2Cdc2ArabidopsisGAIGAIGaiGAIE.

coliuvrAUvrAUvrAUvrAYeastNOTE TO THE READERMolecular Biology of the Cell, Sixth Edition: The Problems Bookby John Wilson and Tim Hunt (ISBN: 978-0-8153-4453-7)The Problems Book is designed to help students appreciate the ways in whichexperiments and simple calculations can lead to an understanding of how cellswork. It provides problems to accompany Chapters 1–20 of Molecular Biologyof the Cell. Each chapter of problems is divided into sections that correspond tothose of the main textbook and review key terms, test for understanding basicconcepts, pose research-based problems, and now include MCAT-style questionswhich help students to prepare for standardized medical school admission tests.Molecular Biology of the Cell, Sixth Edition: The Problems Book should be usefulfor homework assignments and as a basis for class discussion. It could even provide ideas for exam questions.

Solutions for all of the problems are provided in thebook. Solutions for the end-of-chapter problems for Chapters 1–24 in the maintextbook are also found in The Problems Book.RESOURCES FOR INSTRUCTORS AND STUDENTSThe teaching and learning resources for instructors and students are availableonline. The instructor’s resources are password-protected and available only toadopting instructors. The student resources are available to everyone. We hopethese resources will enhance student learning and make it easier for instructors toprepare dynamic lectures and activities for the classroom.Instructor ResourcesInstructor Resources are available on the Garland Science Instructor’s ResourceSite, located at www.garlandscience.com/instructors.

The website provides accessnot only to the teaching resources for this book but also to all other Garland Science textbooks. Adopting instructors can obtain access to the site from their salesrepresentative or by emailing science@garland.com.Art of Molecular Biology of the Cell, Sixth EditionThe images from the book are available in two convenient formats: PowerPoint®and JPEG. They have been optimized for display on a computer. Figures aresearchable by figure number, by figure name, or by keywords used in the figurelegend from the book.Figure-Integrated Lecture OutlinesThe section headings, concept headings, and figures from the text have been integrated into PowerPoint presentations.

These will be useful for instructors whowould like a head start creating lectures for their course. Like all of our PowerPointpresentations, the lecture outlines can be customized. For example, the content ofthese presentations can be combined with videos and questions from the book orQuestion Bank, in order to create unique lectures that facilitate interactive learning.Animations and VideosThe 174 animations and videos that are available to students are also available onthe Instructor’s Website in two formats.

The WMV-formatted movies are createdfor instructors who wish to use the movies in PowerPoint presentations on Windows® computers; the QuickTime-formatted movies are for use in PowerPointfor Apple computers or Keynote® presentations. The movies can easily be downloaded using the “download” button on the movie preview page. The movies arecorrelated to each chapter and callouts are highlighted in color.Media GuideThis document provides an overview to the multimedia available for students andinstructors and contains the text of the voice-over narration for all of the movies.Question BankWritten by Hossein Amiri, University of California, Santa Cruz, this greatlyexpanded question bank includes a variety of question formats: multiple choice,xixiiNOTE TO THE READERshort answer, fill-in-the-blank, true-false, and matching.

There are 35–60 questions per chapter, and a large number of the multiple-choice questions will besuitable for use with personal response systems (that is, clickers). The QuestionBank was created with the philosophy that a good exam should do much morethan simply test students’ ability to memorize information; it should require themto reflect upon and integrate information as a part of a sound understanding. Thisresource provides a comprehensive sampling of questions that can be used eitherdirectly or as inspiration for instructors to write their own test questions.Diploma® Test Generator SoftwareThe questions from the Question Bank have been loaded into the Diploma TestGenerator software.

The software is easy to use and can scramble questions to create multiple tests. Questions are organized by chapter and type and can be additionally categorized by the instructor according to difficulty or subject. Existingquestions can be edited and new ones added. The Test Generator is compatiblewith several course management systems, including Blackboard®.Medical Topics GuideThis document highlights medically relevant topics covered throughout MolecularBiology of the Cell and The Problems Book. It will be particularly useful for instructors with a large number of premedical, health science, or nursing students.Blackboard and Learning Management System (LMS) IntegrationThe movies, book images, and student assessments that accompany the bookcan be integrated into Blackboard or other LMSs.

These resources are bundledinto a “Common Cartridge” or “Upload Package” that facilitates bulk uploadingof textbook resources into Blackboard and other LMSs. The LMS CommonCartridge can be obtained on a DVD from your sales representative or by emailingscience@garland.com.Resources for StudentsThe resources for students are available on the Molecular Biology of the CellStudent Website, located at www.garlandscience.com/MBOC6-students.Animations and VideosThere are 174 movies, covering a wide range of cell biology topics, which reviewkey concepts in the book and illuminate subcellular processes.

The movies arecorrelated to each chapter and callouts are highlighted in color.Cell Explorer SlidesThis application teaches cell morphology through interactive micrographs thathighlight important cellular structures.FlashcardsEach chapter contains a set of flashcards, built into the website, that allow students to review key terms from the text.GlossaryThe complete glossary from the book is available on the website and can besearched and browsed.xiiiAcknowledgmentsIn writing this book we have benefited greatly from the advice of many biologists and biochemists. We would like to thankthe following for their suggestions in preparing this edition, as well as those who helped in preparing the first, second,third, fourth, and fifth editions.

(Those who helped on this edition are listed first, those who helped with the first, second,third, fourth, and fifth editions follow.)General:Steven Cook (Imperial College London), Jose A. Costoya(Universidade de Santiago de Compostela), Arshad Desai(University of California, San Diego), Susan K. Dutcher(Washington University, St. Louis), Michael Elowitz(California Institute of Technology), Benjamin S.

Glick(University of Chicago), Gregory Hannon (Cold SpringHarbor Laboratories), Rebecca Heald (University ofCalifornia, Berkeley), Stefan Kanzok (Loyola UniversityChicago), Doug Kellogg (University of California, SantaCruz), David Kimelman (University of Washington, Seattle),Maria Krasilnikova (Pennsylvania State University), WernerKühlbrandt (Max Planck Institute of Biophysics), LewisLanier (University of California, San Francisco), AnnetteMüller-Taubenberger (Ludwig Maximilians University),Sandra Schmid (University of Texas Southwestern), RonaldD. Vale (University of California, San Francisco), D. EricWalters (Chicago Medical School), Karsten Weis (SwissFederal Institute of Technology)Chapter 2: H.

Lill (VU University)Chapter 3: David S. Eisenberg (University of California,Los Angeles), F. Ulrich Hartl (Max Planck Institute ofBiochemistry), Louise Johnson (University of Oxford),H. Lill (VU University), Jonathan Weissman (University ofCalifornia, San Francisco)Chapter 4: Bradley E. Bernstein (Harvard Medical School),Wendy Bickmore (MRC Human Genetics Unit, Edinburgh),Jason Brickner (Northwestern University), Gary Felsenfeld(NIH), Susan M. Gasser (University of Basel), Shiv Grewal(National Cancer Institute), Gary Karpen (University ofCalifornia, Berkeley), Eugene V.

Koonin, (NCBI, NLM,NIH), Hiten Madhani (University of California, SanFrancisco), Tom Misteli (National Cancer Institute),Geeta Narlikar (University of California, San Francisco),Maynard Olson (University of Washington, Seattle),Stephen Scherer (University of Toronto), Rolf Sternglanz(Stony Brook University), Chris L. Woodcock (Universityof Massachusetts, Amherst), Johanna Wysocka and labmembers (Stanford School of Medicine)Chapter 5: Oscar Aparicio (University of SouthernCalifornia), Julie P. Cooper (National Cancer Institute), NeilHunter (Howard Hughes Medical Institute), Karim Labib(University of Manchester), Joachim Li (Universityof California, San Francisco), Stephen West (CancerResearch UK), Richard D. Wood (University of PittsburghCancer Institute)Chapter 6: Briana Burton (Harvard University), RichardH.

Ebright (Rutgers University), Daniel Finley (HarvardMedical School), Michael R. Green (University ofMassachusetts Medical School), Christine Guthrie(University of California, San Francisco), Art Horwich (YaleSchool of Medicine), Harry Noller (University of California,Santa Cruz), David Tollervey (University of Edinburgh),Alexander J. Varshavsky (California Institute of Technology)Chapter 7: Adrian Bird (The Wellcome Trust Centre, UK),Neil Brockdorff (University of Oxford), Christine Guthrie(University of California, San Francisco), Jeannie Lee(Harvard Medical School), Michael Levine (Universityof California, Berkeley), Hiten Madhani (Universityof California, San Francisco), Duncan Odom (CancerResearch UK), Kevin Struhl (Harvard Medical School),Jesper Svejstrup (Cancer Research UK)Chapter 8: Hana El-Samad [major contribution](University of California, San Francisco), Karen Hopkin[major contribution], Donita Brady (Duke University),David Kashatus (University of Virginia), Melanie McGill(University of Toronto), Alex Mogilner (University ofCalifornia, Davis), Richard Morris (John Innes Centre, UK),Prasanth Potluri (The Children’s Hospital of PhiladelphiaResearch Institute), Danielle Vidaurre (University ofToronto), Carmen Warren (University of California, LosAngeles), Ian Woods (Ithaca College)Chapter 9: Douglas J.