Van Eyk, Dunn - Proteomic and Genomic Analysis of Cardiovascular Disease - 2003 (522919), страница 3
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J. Marian and Michael H. GollobIntroduction 341Human Genome 342Genomics and the Process of Drug Discovery 343Genomics and Target Identification 343Genomics and Target Validation 347Genomics and Lead Identification and Refinement 349Genomics and Lead Validation 351Genomics and Individualization of Drug Therapy 352Acknowledgements 354References 35419.319.3.119.3.219.3.319.3.419.3.52121.121.221.321.3.121.3.221.3.321.3.421.421.521.621.6.121.6.221.6.321.6.421.6.5339341Proteomics: A Post-Genomic Platformfor Drug Discovery and Development 359Stephen T. RapundaloPerspectives on the Drug Discovery and Development Process 360Emerging Proteomic Technologies in R & D 365Target Identification 369Cardiovascular Diseases 369Cancer 372Infectious Diseases 372Inflammation and Immune Function 373Target/Drug Validation 373Toxicoproteomics 375Biomarker Discovery 377Cardiovascular Diseases 377Cancer 378Neurological Diseases 379Inflammatory Diseases 380Infectious Diseases 381Contents21.6.621.721.8Miscellaneous Diseases 381The Changing Pharmaceutical R & D Landscape 381References 383Subject Index391XVIIXIXList of ContributorsLawrence AdamsDepartment of PathologyUniversity of WashingtonBox 357335, 1959 NE Pacific StreetSeattle, WA 98195-7335USARuedi AebersoldInstitute for Systems Biology1441 North 34th StreetSeattle, WA 98103-8904USAE-mail: raebersold@systemsbiology.orghttp://www.systemsbiology.orgCynthia A.
AfshariMicroarray GroupNational Institute of EnvironmentalHealth Sciences, NIH111 Alexander DriveResearch Triangle Park, NC 27709USAE-mail: afshari@niehs.nih.govhttp://div.niehs.nih.gov/microarray/home.htmAlfred C. AplinDepartment of PathologyUniversity of WashingtonSeattle, WA 98195-7335USASara ArabHeart & StrokeRichard Lewar Center of ExcellenceEN 12-324Toronto General Research Institute200 Elizabeth StreetToronto, ON M5G 2C4CanadaBradford C.
BerkAab Institute of Biomedical SciencesUniversity of Rochester601 Elmwood AvenueRochester, NY, 14642USAE-mail:bradford_berk@urmc.rochester.eduRoger E. BumgarnerDepartments of MicrobiologyUniversity of WashingtonSeattle, WA 98195USAE-mail: rogerb@u.washington.eduAtul J.
ButteChildren’s Hospital InformaticsProgram320 Longwood AvenueBoston, MA 02115E-mail: atul_butte@harvard.eduhttp://www.chip.orgProteomic and Genomic Analysis of Cardiovascular Disease.Edited by Jennifer E. van Eyk, Michael J. DunnCopyright © 2003 WILEY-VCH Verlag GmbH & Co. KGaA, WeinheimISBN: 3-527-30596-3XXList of ContributorsHelen L. ByersProteome Sciences plcInstitute of PsychiatryKings College, De Crespigny ParkLondon, SE5 8AFUKChristophe DepreCardiovascular Research InstituteUniversity of Medicine and DentistryNew Jersey Medical School185 South Orange AvenueNewark, NJ 07103USAE-mail: deprech@umdnj.eduMichael J.
DunnDepartment of NeurosciencesInstitute of PsychiatryKings College, De Crespigny ParkLondon, SE5 8AFUKE-mail: m.dunn@iop.kcl.ac.ukJoe G. N. GarciaDivision of Pulmonary and CriticalCare MedicineJohns Hopkins University Schoolof Medicine5501 Hopkins Bayview CircleBaltimore, MD 21224USAE-mail: drgarcia@jhmi.eduMichael H. GollobSection of CardiologyBaylor College of MedicineOne Baylor Plaza, 506DHouston, TX, 77030USARoberta A. GottliebDepartment of Molecular& Experimental MedicineThe Scripps Research Institute MEM22010550 N. Torrey Pines RoadLa Jolla, CA 92037USAE-mail: robbieg@scripps.eduTimothy A. J. HaysteadDepartment of Pharmacologyand Cancer BiologyCenter for Chemical BiologyDuke University Medical CenterDurham, NC 27710USAE-mail: hayst001@mc.duke.eduhttp://pharmacology.mc.duke.eduHuaping HeDepartment of Molecular& Experimental MedicineThe Scripps Research InstituteMitoKor, 11494 Sorrento Valley RoadSan Diego, CA 92121USAE-mail: hej@mitokor.comMansoor HusainHeart & StrokeRichard Lewar Center of ExcellenceEN 12-324Toronto General Research Institute200 Elizabeth StreetToronto, ON M5G 2C4CanadaSteven D.
IscoeDepartment of PhysiologyQueen’s UniversityKingston ON, K7L 3N6CanadaE-mail: iscoes@post.queensu.caList of ContributorsSeigo IzumoBeth Israel Deaconess Medical Center330 Longwood AvenueBoston, MA 02215USAE-mail: sizumo@caregroup.harvard.eduRosalind E. JenkinsDepartment of HumanAnatomy & Cell BiologyUniversity of LiverpoolAshton StreetLiverpool, L69 3GEUKE-mail: r.jenkins@liverpool.ac.ukZheng-Gen JinCenter for Cardiovascular ResearchUniversity of Rochester601 Elmwood AvenueRochester, NY 14642USAE-mail:zheng-gen_jin@urwc.rochester.eduMaike KrenzDivision of Molecular CardiovascularBiology, MLC 7020Children’s Hospital Research Foundation3333 Burnet AvenueCincinnati, OH 45229-3039USADuan-Fang LiaoCenter for Cardiovascular ResearchUniversity of Rochester601 Elmwood AvenueRochester, NY 14642USAChoong Chin LiewCardiovascular Genome UnitBrigham and Women’s HospitalHarvard Medical School75 Francis Street Thorn 1334Boston, MA 02115E-mail: Cliew@rics.bwh.harvard.eduPeter LiuHeart & StrokeRichard Lewar Center of ExcellenceEN 12-324Toronto General Research Institute200 Elizabeth StreetToronto, ON M5G 2C4CanadaE-mail: peter.liu@utoronto.caShwu-Fan MaDivision of Pulmonary and CriticalCare MedicineJohns Hopkins University Schoolof Medicine5501 Hopkins Bayview CircleBaltimore, MD 21224USAJustin A.
MacDonaldDepartment of Pharmacologyand Cancer BiologyCenter for Chemical BiologyDuke University Medical CenterDurham, NC 27710USAAli J. MarianSection of CardiologyBaylor College of MedicineOne Baylor Plaza, 506DHouston, TX 77030USAE-mail: amarian@bcm.tmc.eduhttp://public.bcm.tmc.eduXXIXXIIList of ContributorsEmma McGregorProteome Sciences plcInstitute of PsychiatryKings College, De Crespigny ParkLondon, SE5 8AFUKElizabeth MurphyLaboratory of Signal TransductionNational Institute of EnvironmentalHealth Sciences, NIEHS111 Alexander DriveResearch Triangle Park, NC 27709USAE-mail: murphy1@niehs.nih.govhttp://dir.niehs.nih.gov/dirlst/home.htmCharles E. MurryDepartment of PathologyBox 357470University of WashingtonSeattle, WA 98195-7335USAE-mail: murry@u.washington.eduStephan R.
PenningtonDepartment of HumanAnatomy & Cell BiologyUniversity of LiverpoolAshton StreetLiverpool, L69 3GEUKE-mail: srpenn@liv.ac.ukhttp://www.liv.ac.uk/hacbJohn G. PetrankaLaboratory of Signal TransductionNational Institute of EnvironmentalHealth Sciences, NIH111 Alexander DriveResearch Triangle Park, NC 27709USAE-mail: petranka@niehs.nih.govPeipei PingCardiology Research, Departmentof Physiology & Biophysics, Suite 122Baxter Biomedical Research Building570 South Preston St.Louisville, KY 40202-1783USAE-mail: ping@ntr.nethttp://Louisville.edu/medschool/physiologyStephen T.
RapundaloDepartment of CardiovascularMolecular SciencesPfizer Global R & DAnn Arbor Laboratories2800 Plymouth RoadAnn Arbor, MI 48105USAE-mail: stephen.rapundalo@pfizer.comLauren RiggiBeth Israel Deaconess Medical CenterHarvard Medical School300 Longwood AvenueBoston, MA 02115USAE-mail: lriggi@caregroup.harvard.eduJeffrey RobbinsDivision of Molecular CardiovascularBiology, MLC 7020Children’s Hospital Research Foundation3333 Burnet AvenueCincinnati, OH 45229-3039USAE-mail: jeff.robbins@chmcc.orghttp://www.cincinnatichildrens.orgList of ContributorsMartina SchinkeBeth Israel Deaconess Medical CenterCardiovascular Division SL 215330 Brookline Ave.Boston, MA 02215USAE-mail:mschinke@caregroup.harvard.eduhttp://www.cardiogenomics.orgStephen M. SchwartzDepartment of PathologyUniversity of WashingtonBox 357335, 1959 NE Pacific StreetSeattle, WA 98195-7335USAE-mail: steves@u.washington.eduGary SchwartzbauerDivision of Molecular CardiovascularBiology, MLC 7020Children’s Hospital Research Foundation3333 Burnet AvenueCincinnati, OH 45229-3039USAJeremy A.
SimpsonDepartment of PhysiologyQueen’s UniversityKingston ON, K7L 3N6CanadaCharles SteenbergenDepartment of PathologyDuke University Medical CenterDurham, NC 27710USAE-mail: Steen001@mc.duke.eduTiina T. TuomistoA.I. Virtanen Institute of MolecularSciencesUniversity of KuopioP.O. Box 1627FIN-70211 KuopioFinlandE-mail: Tiina.Tuomisto@uku.fiJennifer E. Van EykDepartment of PhysiologyQueen’s UniversityKingston ON, K7L 3N6CanadaE-mail: jve1@post.queensu.cahttp://meds.queensu.ca/medicine/physiol/about.htmlThomas M. VondriskaDepartments of Physiology& Biophysics and MedicineDivision of CardiologyUniversity of LouisvilleLouisville, KY 40202USAE-mail: tvondriska@hotmail.comMalcolm A.
WardProteome Sciences plcInstitute of PsychiatryKings College, De Crespigny ParkBox P045, South Wing LaboratoryLondon, SE5 8AFUKE-mail: m.ward@iop.kcl.ac.ukMichael E. WrightInstitute for Systems Biology1441 North 34th StreetSeattle, WA 98103USAE-mail: mwright@systemsbiology.orgXXIIIXXIVList of ContributorsChen YanCenter for Cardiovascular ResearchUniversity of Rochester601 Elmwood AvenueRochester, NY 14642USAE-mail: chen_yan@urmc.rochester.eduShui Qing YeDivision of Pulmonary and CriticalCare MedicineJohns Hopkins University School ofMedicine5501 Hopkins Bayview CircleBaltimore, MD 21224USASeppo Ylä-HerttualaA.I. Virtanen Institute of MolecularSciencesUniversity of KuopioP.O. Box 1627FIN-70211 KuopioFinlandE-mail: Seppo.Ylaherttuala@uku.fihttp:/www.uku.fi/laitokset/aivi/index.htmJun ZhangDepartments of Physiology& Biophysics and MedicineDivision of CardiologyUniversity of LouisvilleLouisville, KY 40202USAE-mail: J0Zeng1@louisville.eduXXVAbbreviations2DEACATADMEAng IIApoApoEASMCAvg DiffBADBcl-2CALICBBcDNACICIDCIEFCNLCNSCSCOPDCSFCuZnSODCVCZEDCMDIGEDTTEgr-1EHEIERKESIESTtwo-dimensional polyacrylamide-gel electrophoresisacyl coenzyme A-cholesterol acyltransferaseabsorption, distribution, metabolism, elimination/excretionangiotensin IIapolipoproteinapolipoprotein Earterial smooth muscle cellsaverage differencebipolar affective disorderB-cell leukemia/lymphoma 2chromophore-assisted laser inactivationcolloidal coomassie bluecomplementary DNAchemical ionisationcollision induced dissociationcapillary isoelectric focusingconstant neutral losscentral nervous systemcyclic stretchchronic obstructive pulmonary diseasecolony stimulating factorcytosolic copper/ zinc-containing superoxide dismutasecardiovascularcapillary zone electrophoresisdilated cardiomyopathydifferential gel electrophoresisdithiothreitolearly growth response 1enoyl-CoA-hydrataseelectron impactextracellular signal regulated kinaseelectro spray ionizationexpressed sequence tagProteomic and Genomic Analysis of Cardiovascular Disease.Edited by Jennifer E.
van Eyk, Michael J. DunnCopyright © 2003 WILEY-VCH Verlag GmbH & Co. KGaA, WeinheimISBN: 3-527-30596-3XXVIAbbreviationsFALIFDAFGFFHCFTICRFPPGABAGISTGOLDGPXHAECHCMHFHGPHIVHMG Co AlHPLC-ESI-MS/MSHTSHUVECICAMICATTMIEFIFN-cIGF-1ILIPGIPPLCLDLLSSLVMASMDLCMGEDMHCMMMMAC1MMPMnSODmRNAMSMudPITNF-jBNOfluorophore assisted light inactivationFederal Drug Administrationfibroblast growth factorfamilial hypertrophic cardiomyopathyfourier transform ion cyclotron resonance mass spectrometryfarnesyl pyrophosphatec-aminobutyric acidglobal internal standard technologygenomics online databaseglutathione peroxidasehuman arterial endothelial cellshypertrophic cardiomyopathyheart failurehuman genome projecthuman immunodeficiency virushydroxy methylglutaryl coenzyme A synthasemicrocapillary reversed-phase high performance liquid chromatography electrospray ionization tandem mass spectrometryhigh throughput screeninghuman umbilical vein endothelial cellsintracellular adhesion moleculeisotope-coded affinity tagsisoelectric focusinginterferon-cinsulin like growth factor-1interleukinimmobilized pH gradientisopentenyl-diphosphate d-isomeraseliquid chromatographylow density lipoproteinlaminar shear stressleft ventricleAffymetrix® Microarray Suitemultidimensional liquid chromatographymicroarray gene expression databasemyosin heavy chainmismatchmutated in multiple advanced cancers-1matrix metalloproteinasesmitochondrial manganese-containing superoxide dismutasemessenger RNAmass spectrometrymultidimensional protein identification technologynuclear factor-jBnitric oxideAbbreviationsNSAIDPCRPDGFPECAMpIPIP2PIP3PKPKCePMPMAPMFPPARPPIasePSDPTENPTMQ-TOFROSR&DRP-HPLCRT-PCRRT-PCRSAGESARSCASDS-PAGESELDISMCSNPSOMSOXFSQSTAPTEP1THP-1TIMPTNFaTSSUCHUVVCAMVEGFVLDLWHHLnon-steroidal anti-inflammatory drugspolymerase chain reactionplatelet-derived growth factorplatelet-endothelial cell adhesion moleculeisoelectric pointphosphatidylinositol 3,4-biphosphatephosphatidylinositol 3,4,5-triphosphatepharmacokineticprotein kinase C-epsilonperfect matchphorbol 12-myristate 13-acetatepeptide mass fingerprintingperoxisome proliferator-activated receptorspeptidyl-prolyl cis-trans isomerasepost-source decayphosphatase and tensin homologue on chromosome tenpost-translational modificationquadrupole time of flightreactive oxygen speciesResearch & Developmentreversed-phase high performance liquid chromatographyreal time polymerase chain reactionreverse transcriptase PCRserial analysis of gene expressionstructure activity relationshipsynthetic carrier ampholytessodium dodecyl sulfate polyacrylamide gel electrophoresissurface enhanced laser desorption/ionizationsmooth muscle cellsingle nucleotide polymorphismself-organizing mapsecreted oxidative stress-induced factorssqualene synthasetandem affinity purificationTGF-regulated, epithelial cell enriched phosphatasehuman monocyte/macrophage cell linetissue inhibitor of metalloproteinasetumor necrosis factor aturbulent shear stressubiquitin carboxyl-terminal hydrolaseultra violetvascular cell adhesion moleculevascular endothelial growth factorvery low density lipoproteinWatanabe heritable hyperlipidemicXXVIISection 1GenomicsProteomic and Genomic Analysis of Cardiovascular Disease.Edited by Jennifer E.
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