91224 (Диференційовані підходи до корекції метаболічних порушень у хворих на гнійний середній отит), страница 4

Ключевые слова: острый и хронический гнойный средний отит, остеопения, криоглобулины, лечение.

ANNOTATION

Malyovana I.V. Differentiated approaches to correction of metabolic violations in patients on purulent otitis media. – Manuscript.

Dissertation on gaining a scientific degree of candidate of medical sciences after speciality 14.01.19. – otorynolaryngology. – Ternopil state medical university named by I.Ya. Gorbachevsciy MOZ of Ukraine, Ternopil, 2008.

Dissertation is devoted to the questions of rise of efficiency of diagnostics and medical treatment of complications of purulent otitis media. Were explored saturation of bones by the mineral matters, metabolism of connecting tissue, caltsium-phosphor exchange, state of immunity system and intensity of inflammatory component depending on the clinical variant of otitis. Because of even prevalence of osteopaty patients on purulent otitis media (at APOM – 50,0 %, at CPOM – 40,0 %), protracted, clinically the more heavy motion of chronic inflammatory process in the middle whisker assists to the greater decline of mineralizatsion of bone tissue. Is a certificate of this diagnosed at chronic purulent otitis of the osteopeny I-II degree (20,0 %) and osteoporozis (11,43 %), while at acute took place only the osteopeny I-II degree. Selected laboratory and instrumental criterium of finding out of the osteopeny at patients with acute and chronic purulent otitis media depending on duration of disease and frequency of acutening. Among them the leading role belongs to determination to the calcium, ocsiprolini, criogloboulini and to estimation of densitogramm after the indexes of standard deviation.

Patogenetic grounded expedience and charts of correction of osteopeny at patients with purulent otitis media are offered by «Caltsemin». An improvement of state of mineralizatsion of bone tissue, stabilization of exchange of spolouchnotcaninnih elements, reduction of intensity of inflammatory component after application of modified charts of medical treatment is watched in dynamics. The secondary immunodeficitis of cellular link of immunity the ІІ degree and by the disimounogloboulinemy corected with preparation «Proteflazid», efficiency of which is led to the positive clinical laboratory dynamics.

Keywords: acute and chronic purulent otitis media, osteopeny, criogloboulini, medical treatment.

ПЕРЕЛІК УМОВНИХ ПОЗНАЧЕНЬ

КГ – кріоглобуліни

ІН – імунодефіцит

ЛФ – лужна фосфатаза

ОП – оксипролін

ХГСО – хронічний гнійний середній отит

ГГСО – гострий гнійний середній отит

ЦП – церулоплазмін

ВМС – вміст иінеральних речовин у кістці

СD3 – Т-клітини

CD72 – В-клітини

CD4 – Т-хелепери

CD8 – Т-супресори

CD16 – натуральні кілери

Ig – імуноглобуліни

Т – величина стандартного відхилення фактичної мінеральної щільності по відношенню до відповідного середньовікового показника